UniProt Q53GL7
Poly [ADP-ribose] polymerase 10 (Q53GL7)
Poly [ADP-ribose] polymerase 10 (UniProt Q53GL7), EC 2.4.2.30: 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q53GL7
- Protein
- Poly [ADP-ribose] polymerase 10
- EC
- 2.4.2.30
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 27 · 5 records with a druggable one
Structures
7 records of Q53GL7 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3HKV | Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor… | x-ray diffraction | A, B | PO4, NA, 3AB | 5 (best 0.76) |
| 3HKV | Human POLY(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor… | x-ray diffraction | A, B | PO4, NA, 3AB | 5 (best 0.76) |
| 5LX6 | Human PARP10 (ARTD10), catalytic fragment in complex with PARP inhibitor Veliparib | x-ray diffraction | A, B | 78P | 3 (best 0.77) |
| 5LX6 | Human PARP10 (ARTD10), catalytic fragment in complex with parp inhibitor veliparib | x-ray diffraction | A, B | 78P | — |
| 6FXI | Human PARP10 (ARTD10), catalytic fragment in complex with 3-aminobenzamide and citrate | x-ray diffraction | A, B | 3AB | 4 (best 0.73) |
| 6FXI | Human PARP10 (ARTD10), catalytic fragment in complex with 3- aminobenzamide and citrate | x-ray diffraction | A, B | 3AB | — |
| Q53GL7 | AlphaFold monomer V2.0 prediction for protein mono-ADP- ribosyltransferase PARP10 (Q53GL7) | predicted | A | — | 10 (best 0.77) |
Ligands
Experiment against prediction
- 6FXI chain A against the predicted model Q53GL7: TM-score 0.99, RMSD 0.67 Å
- 6FXI chain A against the predicted model Q53GL7: TM-score 0.99, RMSD 0.67 Å
- 6FXI chain B against the predicted model Q53GL7: TM-score 0.99, RMSD 0.67 Å
- 6FXI chain B against the predicted model Q53GL7: TM-score 0.99, RMSD 0.67 Å
- 3HKV chain B against the predicted model Q53GL7: TM-score 0.98, RMSD 0.69 Å
- 3HKV chain B against the predicted model Q53GL7: TM-score 0.98, RMSD 0.69 Å
- 3HKV chain A against the predicted model Q53GL7: TM-score 0.98, RMSD 0.79 Å
- 3HKV chain A against the predicted model Q53GL7: TM-score 0.98, RMSD 0.79 Å
- 5LX6 chain B against the predicted model Q53GL7: TM-score 0.98, RMSD 0.82 Å
- 5LX6 chain B against the predicted model Q53GL7: TM-score 0.98, RMSD 0.82 Å
Elsewhere
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