UniProt Q53G59
Kelch-like protein 12 (Q53G59)
Kelch-like protein 12 (UniProt Q53G59): 8 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q53G59
- Protein
- Kelch-like protein 12
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 30 · 6 records with a druggable one
Structures
9 records of Q53G59 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VPJ | Crystal structure of the Kelch domain of human KLHL12 | x-ray diffraction | A | — | 1 (best 0.73) |
| 2VPJ | Crystal structure of the kelch domain of human KLHL12 | x-ray diffraction | A | — | — |
| 6TTK | Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide | x-ray diffraction | A, B, C, D | NA, CL | 11 (best 0.76) |
| 6TTK | Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide | x-ray diffraction | A, B, C, D | NA, CL | — |
| 6V7O | Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a… | x-ray diffraction | A, B | — | 4 (best 0.84) |
| 6V7O | Structural elucidation of peptide binding to klhl-12, a substrate specific adapter protein in a… | x-ray diffraction | A, B | — | — |
| 8OIO | Crystal structure of the kelch domain of human KLHL12 in complex with PLEKHA4 peptide | x-ray diffraction | A, B, C, D | CL, NA | 8 (best 0.74) |
| 8RBH | Crystal structure of the kelch domain of human KLHL12 in complex with PEF1 peptide | x-ray diffraction | A, B | NA | 4 (best 0.83) |
| Q53G59 | AlphaFold monomer V2.0 prediction for kelch-like protein 12 (Q53G59) | predicted | A | — | 2 (best 0.80) |
Ligands
Experiment against prediction
- 6TTK chain C against the predicted model Q53G59: TM-score 0.99, RMSD 0.67 Å
- 6TTK chain C against the predicted model Q53G59: TM-score 0.99, RMSD 0.67 Å
- 6V7O chain B against the predicted model Q53G59: TM-score 0.99, RMSD 0.68 Å
- 6V7O chain B against the predicted model Q53G59: TM-score 0.99, RMSD 0.68 Å
- 6TTK chain A against the predicted model Q53G59: TM-score 0.99, RMSD 0.70 Å
- 6TTK chain A against the predicted model Q53G59: TM-score 0.99, RMSD 0.70 Å
- 8OIO chain A against the predicted model Q53G59: TM-score 0.99, RMSD 0.70 Å
- 6V7O chain A against the predicted model Q53G59: TM-score 0.99, RMSD 0.71 Å
- 6V7O chain A against the predicted model Q53G59: TM-score 0.99, RMSD 0.71 Å
- 8OIO chain C against the predicted model Q53G59: TM-score 0.99, RMSD 0.71 Å
Elsewhere
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