UniProt Q53EL6
Programmed cell death protein 4 (Q53EL6)
Programmed cell death protein 4 (UniProt Q53EL6): 13 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q53EL6
- Protein
- Programmed cell death protein 4
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 27 · 5 records with a druggable one
Structures
14 records of Q53EL6 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KZT | Structure of the Tandem MA-3 Region of Pdcd4 | solution nmr | A | — | 2 (best 0.73) |
| 2KZT | Structure of the tandem ma-3 region of PDCD4 | solution nmr | A | — | — |
| 2RG8 | Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain | x-ray diffraction | A, B | CL, NA | 3 (best 0.51) |
| 2RG8 | Crystal structure of programmed for cell death 4 middle MA3 domain | x-ray diffraction | A, B | — | — |
| 2ZU6 | crystal structure of the eIF4A-PDCD4 complex | x-ray diffraction | B, E | — | 12 (best 0.81) |
| 2ZU6 | Crystal structure of the EIF4A-PDCD4 complex | x-ray diffraction | B, E | — | — |
| 3EIJ | Crystal structure of Pdcd4 | x-ray diffraction | A, B | — | 5 (best 0.77) |
| 3EIJ | Crystal structure of PDCD4 | x-ray diffraction | A, B | — | — |
| 8XXL | Cryo-EM structure of the human 40S ribosome with PDCD4 | electron microscopy | CD | — | — |
| 8XXM | Cryo-EM structure of the human 40S ribosome with PDCD4 and eIF3G | electron microscopy | CD | — | — |
| 8XXN | Cryo-EM structure of the human 43S ribosome with PDCD4 | electron microscopy | CD | — | — |
| 9BKD | The structure of human Pdcd4 bound to the 40S small ribosomal subunit | electron microscopy | U | MG | — |
| 9BLN | The structure of human Pdcd4 bound to the 40S-eIF4A-eIF3-eIF1 complex | electron microscopy | p | MG | 1 (best 0.82) |
| Q53EL6 | AlphaFold monomer V2.0 prediction for programmed cell death protein 4 (Q53EL6) | predicted | A | — | 4 (best 0.47) |
Ligands
Experiment against prediction
- 2ZU6 chain B against the predicted model Q53EL6: TM-score 0.99, RMSD 0.52 Å
- 2ZU6 chain B against the predicted model Q53EL6: TM-score 0.99, RMSD 0.52 Å
- 2ZU6 chain E against the predicted model Q53EL6: TM-score 0.99, RMSD 0.61 Å
- 2ZU6 chain E against the predicted model Q53EL6: TM-score 0.99, RMSD 0.61 Å
- 2RG8 chain B against the predicted model Q53EL6: TM-score 0.97, RMSD 1.03 Å
- 2RG8 chain B against the predicted model Q53EL6: TM-score 0.97, RMSD 1.03 Å
- 2RG8 chain A against the predicted model Q53EL6: TM-score 0.96, RMSD 0.88 Å
- 2RG8 chain A against the predicted model Q53EL6: TM-score 0.96, RMSD 0.88 Å
- 2KZT chain A against the predicted model Q53EL6: TM-score 0.89, RMSD 1.96 Å
- 2KZT chain A against the predicted model Q53EL6: TM-score 0.89, RMSD 1.96 Å
Elsewhere
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