UniProt Q53464
L-2-haloacid dehalogenase (Q53464)
L-2-haloacid dehalogenase (UniProt Q53464), EC 3.8.1.2: 8 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q53464
- Protein
- L-2-haloacid dehalogenase
- EC
- 3.8.1.2
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 7 · 2 records with a druggable one
Structures
9 records of Q53464 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JUD | L-2-haloacid dehalogenase | x-ray diffraction | A | — | 2 (best 0.67) |
| 1JUD | L-2-haloacid dehalogenase | x-ray diffraction | A | — | — |
| 1QH9 | Enzyme-product complex of L-2-haloacid dehalogenase | x-ray diffraction | A | LAC | 1 (best 0.45) |
| 1QH9 | Enzyme-product complex of L-2-haloacid dehalogenase | x-ray diffraction | A | — | — |
| 1ZRM | Crystal structure of the reaction intermediate of L-2-haloacid dehalogenase with 2-chloro-N-butyrate | x-ray diffraction | A | BUA | 1 (best 0.44) |
| 1ZRM | Crystal structure of the reaction intermediate of L-2-haloacid dehalogenase with 2-chloro-N-butyrate | x-ray diffraction | A | — | — |
| 1ZRN | Intermediate structure of L-2-haloacid dehalogenase with monochloroacetate | x-ray diffraction | A | — | 2 (best 0.68) |
| 1ZRN | Intermediate structure of L-2-haloacid dehalogenase with monochloroacetate | x-ray diffraction | A | — | — |
| Q53464 | AlphaFold monomer V2.0 prediction for (S)-2-haloacid dehalogenase (Q53464) | predicted | A | — | 1 (best 0.48) |
Ligands
Experiment against prediction
- 1ZRM chain A against the predicted model Q53464: TM-score 1.00, RMSD 0.28 Å
- 1ZRM chain A against the predicted model Q53464: TM-score 1.00, RMSD 0.28 Å
- 1QH9 chain A against the predicted model Q53464: TM-score 1.00, RMSD 0.32 Å
- 1QH9 chain A against the predicted model Q53464: TM-score 1.00, RMSD 0.32 Å
- 1ZRN chain A against the predicted model Q53464: TM-score 0.99, RMSD 0.58 Å
- 1ZRN chain A against the predicted model Q53464: TM-score 0.99, RMSD 0.58 Å
- 1JUD chain A against the predicted model Q53464: TM-score 0.99, RMSD 0.66 Å
- 1JUD chain A against the predicted model Q53464: TM-score 0.99, RMSD 0.66 Å
Elsewhere
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