UniProt Q4WAW9
Verruculogen synthase (Q4WAW9)
Verruculogen synthase (UniProt Q4WAW9), EC 1.14.11.38: 14 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 58 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q4WAW9
- Protein
- Verruculogen synthase
- EC
- 1.14.11.38
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 58 · 7 records with a druggable one
Structures
15 records of Q4WAW9 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4Y5S | Structure of FtmOx1 with a-Ketoglutarate as co-substrate | x-ray diffraction | A, B | AKG, FE2, CO | 6 (best 0.77) |
| 4Y5S | Structure of FTMOX1 with a-ketoglutarate as co-substrate | x-ray diffraction | A, B | — | — |
| 4Y5T | Structure of FtmOx1 apo with metal Iron | x-ray diffraction | A, B | FE2, SO4, CO | 6 (best 0.77) |
| 4Y5T | Structure of FTMOX1 apo with metal iron | x-ray diffraction | A, B | — | — |
| 6OXH | X-ray crystal structure of His-tagged Y140F FtmOx1 bound to Fe(II) and 2-oxoglutarate | x-ray diffraction | A, B | FE2, AKG | 7 (best 0.78) |
| 6OXH | X-ray crystal structure of his-tagged Y140F FTMOX1 bound to FE(II) and 2-oxoglutarate | x-ray diffraction | A, B | FE2, AKG | — |
| 6OXJ | X-ray crystal structure of Y140F FtmOx1 bound to Fe(II) | x-ray diffraction | A, B | FE2 | 7 (best 0.79) |
| 6OXJ | X-ray crystal structure of Y140F FTMOX1 bound to FE(II) | x-ray diffraction | A, B | FE2 | — |
| 7ETK | The complex structure of FtmOx1 bond with fumitremorgen B at 1.22 angstrom | x-ray diffraction | A, B | AKG, FE2, 4Q1 | 6 (best 0.80) |
| 7ETK | The complex structure of FTMOX1 bond with fumitremorgen B at 1.22 ångström | x-ray diffraction | A, B | AKG, FE2, 4Q1 | — |
| 7ETL | The crystal structure of FtmOx1-Y68F | x-ray diffraction | A, B | CO, SO4, CL, AKG, FE2 | 6 (best 0.78) |
| 7ETL | The crystal structure of FTMOX1-Y68F | x-ray diffraction | A, B | CO, SO4, CL, AKG, FE2 | — |
| 7WSB | The ternary complex structure of FtmOx1 with a-ketoglutarate and 13-oxo-fumitremorgin B | x-ray diffraction | A, B, C, D, E, F | CO, 4IL, AKG | 20 (best 0.84) |
| 7WSB | The ternary complex structure of FTMOX1 with a-ketoglutarate and 13- oxo-fumitremorgin B | x-ray diffraction | A, B, C, D, E, F | CO, 4IL, AKG | — |
| Q4WAW9 | AlphaFold monomer V2.0 prediction for verruculogen synthase (Q4WAW9) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6OXJ chain A against the predicted model Q4WAW9: TM-score 1.00, RMSD 0.33 Å
- 6OXJ chain A against the predicted model Q4WAW9: TM-score 1.00, RMSD 0.33 Å
- 7ETL chain B against the predicted model Q4WAW9: TM-score 1.00, RMSD 0.33 Å
- 7ETL chain B against the predicted model Q4WAW9: TM-score 1.00, RMSD 0.33 Å
- 6OXJ chain B against the predicted model Q4WAW9: TM-score 1.00, RMSD 0.38 Å
- 6OXJ chain B against the predicted model Q4WAW9: TM-score 1.00, RMSD 0.38 Å
- 4Y5T chain B against the predicted model Q4WAW9: TM-score 1.00, RMSD 0.40 Å
- 4Y5T chain B against the predicted model Q4WAW9: TM-score 1.00, RMSD 0.40 Å
- 6OXH chain A against the predicted model Q4WAW9: TM-score 0.99, RMSD 0.46 Å
- 6OXH chain A against the predicted model Q4WAW9: TM-score 0.99, RMSD 0.46 Å
Elsewhere
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