UniProt Q4FZB7
Histone-lysine N-methyltransferase KMT5B (Q4FZB7)
Histone-lysine N-methyltransferase KMT5B (UniProt Q4FZB7), EC 2.1.1.361, 2.1.1.362: 11 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 31 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q4FZB7
- Protein
- Histone-lysine N-methyltransferase KMT5B
- EC
- 2.1.1.361, 2.1.1.362, 2.1.1.43
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 31 · 7 records with a druggable one
Structures
12 records of Q4FZB7 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3S8P | Crystal Structure of the SET Domain of Human Histone-Lysine N-Methyltransferase SUV420H1 In Complex… | x-ray diffraction | A, B | — | — |
| 3S8P | Crystal structure of the set domain of human histone-lysine N- methyltransferase SUV420H1 in… | x-ray diffraction | A, B | — | — |
| 5CPR | The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity | x-ray diffraction | B | ZN, SAM, 539 | 3 (best 0.68) |
| 5CPR | The novel SUV4-20 inhibitor a-196 verifies a role for epigenetics in genomic integrity | x-ray diffraction | B | — | — |
| 5WBV | Crystal Structure of the SET Domain of Human SUV420H1 In Complex With Inhibitor | x-ray diffraction | A, B | ZN, SAM, 9ZY, UNX | 3 (best 0.80) |
| 5WBV | Crystal structure of the set domain of human SUV420H1 in complex with inhibitor | x-ray diffraction | A, B | ZN, 9ZY, UNX | — |
| 8JHF | Native SUV420H1 bound to 167-bp nucleosome | electron microscopy | K | ZN, SAM | 6 (best 0.80) |
| 8JHG | Native SUV420H1 bound to 167-bp nucleosome | electron microscopy | K | ZN, SAM | 4 (best 0.87) |
| 8T68 | Crystal Structure of the SET Domain of Human Histone-Lysine N-Methyltransferase SUV420H1 in complex… | x-ray diffraction | A | ZN, SAM, ZKI | 3 (best 0.68) |
| 8T9F | Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1 | electron microscopy | K | SAM | 5 (best 0.75) |
| 8T9H | Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1 | electron microscopy | K | — | 7 (best 0.71) |
| Q4FZB7 | AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase KMT5B (Q4FZB7) | predicted | A | — | — |
Ligands
- SAM · S-adenosylmethionine · in 6 records
- ZN · Zinc ion · in 6 records
- 9ZY · 2-chloro-5-(4-methyl-6-oxo-3-phenylpyrano[2,3-c]pyrazol-1(6H)-yl)benzoic acid · in 2 records
- UNX · Unknown atom or ion · in 2 records
- 539 · 6,7-dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine · in 1 record
- ZKI · 6,7-dichloro-N-[(3R)-oxolan-3-yl]-4-(pyridin-4-yl)phthalazin-1-amine · in 1 record
Experiment against prediction
- 3S8P chain A against the predicted model Q4FZB7: TM-score 0.99, RMSD 0.91 Å
- 3S8P chain A against the predicted model Q4FZB7: TM-score 0.99, RMSD 0.91 Å
- 5WBV chain A against the predicted model Q4FZB7: TM-score 0.99, RMSD 0.77 Å
- 5WBV chain A against the predicted model Q4FZB7: TM-score 0.98, RMSD 1.06 Å
- 8T68 chain A against the predicted model Q4FZB7: TM-score 0.98, RMSD 0.98 Å
- 5CPR chain B against the predicted model Q4FZB7: TM-score 0.98, RMSD 0.94 Å
- 5CPR chain B against the predicted model Q4FZB7: TM-score 0.98, RMSD 1.18 Å
- 5WBV chain B against the predicted model Q4FZB7: TM-score 0.97, RMSD 1.03 Å
- 5WBV chain B against the predicted model Q4FZB7: TM-score 0.97, RMSD 1.26 Å
- 3S8P chain B against the predicted model Q4FZB7: TM-score 0.97, RMSD 1.34 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.