UniProt Q4DA80
Proline racemase A (Q4DA80)
Proline racemase A (UniProt Q4DA80), EC 5.1.1.4: 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q4DA80
- Protein
- Proline racemase A
- EC
- 5.1.1.4
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 14 · 2 records with a druggable one
Structures
9 records of Q4DA80 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1W62 | proline racemase in complex with one molecule of pyrrole-2-carboxylic acid (hemi form) | x-ray diffraction | A, B | PYC | 7 (best 0.75) |
| 1W62 | Proline racemase in complex with one molecule of pyrrole-2-carboxylic acid (hemi form) | x-ray diffraction | A, B | — | — |
| 6HJE | Trypanosoma cruzi proline racemase in complex with inhibitor NG-P27 | x-ray diffraction | A, B | PO4, 7N0 | — |
| 6HJE | Trypanosoma cruzi proline racemase in complex with inhibitor ng-P27 | x-ray diffraction | A, B | PO4, 7N0 | — |
| 6HJF | Trypanosoma cruzi proline racemase in complex with inhibitor BrOxoPA | x-ray diffraction | A, B | SHF | 6 (best 0.78) |
| 6HJF | Trypanosoma cruzi proline racemase in complex with inhibitor broxopa | x-ray diffraction | A, B | SHF | — |
| 6HJG | Trypanosoma cruzi proline racemase in complex with inhibitor OxoPA | x-ray diffraction | A, B | SHF, PO4 | — |
| 6HJG | Trypanosoma cruzi proline racemase in complex with inhibitor oxopa | x-ray diffraction | A, B | SHF, PO4 | — |
| Q4DA80 | AlphaFold monomer V2.0 prediction for proline racemase a (Q4DA80) | predicted | A | — | 1 (best 0.28) |
Ligands
Experiment against prediction
- 6HJF chain A against the predicted model Q4DA80: TM-score 0.99, RMSD 0.55 Å
- 6HJF chain A against the predicted model Q4DA80: TM-score 0.99, RMSD 0.55 Å
- 6HJE chain A against the predicted model Q4DA80: TM-score 0.99, RMSD 0.74 Å
- 6HJE chain A against the predicted model Q4DA80: TM-score 0.99, RMSD 0.74 Å
- 6HJG chain A against the predicted model Q4DA80: TM-score 0.99, RMSD 0.84 Å
- 6HJG chain A against the predicted model Q4DA80: TM-score 0.99, RMSD 0.84 Å
- 1W62 chain A against the predicted model Q4DA80: TM-score 0.99, RMSD 0.74 Å
- 1W62 chain A against the predicted model Q4DA80: TM-score 0.99, RMSD 0.74 Å
- 6HJF chain B against the predicted model Q4DA80: TM-score 0.98, RMSD 0.23 Å
- 6HJF chain B against the predicted model Q4DA80: TM-score 0.98, RMSD 0.23 Å
Elsewhere
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