UniProt Q49610
Formylmethanofuran--tetrahydromethanopterin formyltransferase (Q49610)
Formylmethanofuran--tetrahydromethanopterin formyltransferase (UniProt Q49610), EC 2.3.1.101: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 82 pockets. Binding sites, druggability and experiment…
- UniProt
- Q49610
- Protein
- Formylmethanofuran--tetrahydromethanopterin formyltransferase
- EC
- 2.3.1.101
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 82 · 6 records with a druggable one
Structures
7 records of Q49610 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FTR | FORMYLMETHANOFURAN:TETRAHYDROMETHANOPTERIN formyltransferase from methanopyrus kandleri | x-ray diffraction | A, B, C, D | — | 14 (best 0.76) |
| 1FTR | FORMYLMETHANOFURAN:TETRAHYDROMETHANOPTERIN formyltransferase from methanopyrus kandleri | x-ray diffraction | A, B, C, D | — | 14 (best 0.76) |
| 2FHJ | Crystal structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with… | x-ray diffraction | A, B, C, D | K, MFN, H4Z | 13 (best 0.82) |
| 2FHJ | Crystal structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with… | x-ray diffraction | A, B, C, D | K, MFN, H4Z | 13 (best 0.82) |
| 2FHK | Crystal structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with… | x-ray diffraction | A, B, C, D | K, MFN | 14 (best 0.77) |
| 2FHK | Crystal structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with… | x-ray diffraction | A, B, C, D | K, MFN | 14 (best 0.77) |
| Q49610 | AlphaFold monomer V2.0 prediction for formylmethanofuran-- tetrahydromethanopterin… | predicted | A | — | — |
Ligands
- K · Potassium ion · in 4 records
- MFN · N-[4,5,7-tricarboxyheptanoyl]-L-gamma-glutamyl-N-{2-[4-({5-[(formylamino)methyl]-3-furyl}methoxy) phenyl]ethyl}-D-glutamine · in 4 records
- H4Z · 5-(4-{[1-(2-amino-5-formyl-7-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)ethyl]amino}phenyl)-5-deoxy-1-O-{5-O-[(1,3-dicarboxypropoxy)(hydroxy)phosphoryl]pentofuranosyl}pentitol · in 2 records
Experiment against prediction
- 2FHK chain B against the predicted model Q49610: TM-score 0.99, RMSD 1.01 Å
- 2FHK chain B against the predicted model Q49610: TM-score 0.99, RMSD 1.01 Å
- 2FHK chain A against the predicted model Q49610: TM-score 0.99, RMSD 1.01 Å
- 2FHK chain A against the predicted model Q49610: TM-score 0.99, RMSD 1.01 Å
- 2FHJ chain A against the predicted model Q49610: TM-score 0.99, RMSD 1.02 Å
- 2FHJ chain A against the predicted model Q49610: TM-score 0.99, RMSD 1.02 Å
- 1FTR chain B against the predicted model Q49610: TM-score 0.99, RMSD 1.02 Å
- 1FTR chain B against the predicted model Q49610: TM-score 0.99, RMSD 1.02 Å
- 2FHJ chain B against the predicted model Q49610: TM-score 0.99, RMSD 1.02 Å
- 2FHJ chain B against the predicted model Q49610: TM-score 0.99, RMSD 1.02 Å
Elsewhere
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