UniProt Q46901
CRISPR system Cascade subunit CasA (Q46901)
CRISPR system Cascade subunit CasA (UniProt Q46901): 11 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q46901
- Protein
- CRISPR system Cascade subunit CasA
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 14 · 2 records with a druggable one
Structures
12 records of Q46901 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4QYZ | Crystal structure of a CRISPR RNA-guided surveillance complex, Cascade, bound to a ssDNA target | x-ray diffraction | A | — | — |
| 4QYZ | Crystal structure of a CRISPR RNA-guided surveillance complex, cascade, bound to a ssdna target | x-ray diffraction | A | — | — |
| 4TVX | Crystal structure of the E. coli CRISPR RNA-guided surveillance complex, Cascade | x-ray diffraction | U, I | — | — |
| 4U7U | Crystal structure of RNA-guided immune Cascade complex from E.coli | x-ray diffraction | A, M | — | — |
| 4U7U | Crystal structure of RNA-guided immune cascade complex from E.COLI | x-ray diffraction | A, M | — | — |
| 5CD4 | The Type IE CRISPR Cascade complex from E. coli, with two assemblies in the asymmetric unit… | x-ray diffraction | I, U | ZN | 7 (best 0.85) |
| 5CD4 | The type ie CRISPR cascade complex from E. COLI, with two assemblies in the asymmetric unit… | x-ray diffraction | I, U | — | — |
| 5H9E | Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target (32-nt spacer) at 3.20… | x-ray diffraction | A | ZN | 7 (best 0.85) |
| 5H9E | Crystal structure of E. COLI cascade bound to a pam-containing dsdna target (32-nt spacer) at 3.20… | x-ray diffraction | A | — | — |
| 5H9F | Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target at 2.45 angstrom… | x-ray diffraction | A | ZN | — |
| 5H9F | Crystal structure of E. COLI cascade bound to a pam-containing dsdna target at 2.45 ångström… | x-ray diffraction | A | — | — |
| Q46901 | AlphaFold monomer V2.0 prediction for CRISPR system cascade subunit casa (Q46901) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 3 records
Experiment against prediction
- 4U7U chain A against the predicted model Q46901: TM-score 0.98, RMSD 1.23 Å
- 4U7U chain A against the predicted model Q46901: TM-score 0.98, RMSD 1.23 Å
- 4U7U chain M against the predicted model Q46901: TM-score 0.98, RMSD 1.25 Å
- 4U7U chain M against the predicted model Q46901: TM-score 0.98, RMSD 1.25 Å
- 5CD4 chain U against the predicted model Q46901: TM-score 0.97, RMSD 1.30 Å
- 5CD4 chain U against the predicted model Q46901: TM-score 0.97, RMSD 1.30 Å
- 5CD4 chain I against the predicted model Q46901: TM-score 0.97, RMSD 1.36 Å
- 5CD4 chain I against the predicted model Q46901: TM-score 0.97, RMSD 1.36 Å
- 4QYZ chain A against the predicted model Q46901: TM-score 0.97, RMSD 1.44 Å
- 4QYZ chain A against the predicted model Q46901: TM-score 0.97, RMSD 1.44 Å
Elsewhere
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