UniProt Q2NKJ3
CST complex subunit CTC1 (Q2NKJ3)
CST complex subunit CTC1 (UniProt Q2NKJ3): 11 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 62 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q2NKJ3
- Protein
- CST complex subunit CTC1
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 62 · 5 records with a druggable one
Structures
12 records of Q2NKJ3 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5W2L | Structure of a central domain of human Ctc1 | x-ray diffraction | A, B | HG | 1 (best 0.28) |
| 5W2L | Structure of a central domain of human CTC1 | x-ray diffraction | A, B | HG | — |
| 6W6W | Cryo-EM structure of CST bound to telomeric single-stranded DNA | electron microscopy | A, B | ZN | 17 (best 0.76) |
| 6W6W | Cryo-EM structure of cst bound to telomeric single-stranded DNA | electron microscopy | A, B | ZN | — |
| 7U5C | Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | E | ZN | 7 (best 0.84) |
| 7U5C | Cryo-EM structure of human cst bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | E | ZN | — |
| 8D0B | Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template | electron microscopy | A | — | 7 (best 0.82) |
| 8D0B | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template | electron microscopy | A | — | — |
| 8D0K | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template… | electron microscopy | A | — | — |
| 8SOJ | Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the absence of telomeric ssDNA | electron microscopy | A | ZN | 16 (best 0.83) |
| 8SOK | Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA | electron microscopy | A | ZN | 14 (best 0.84) |
| Q2NKJ3 | AlphaFold monomer V2.0 prediction for cst complex subunit CTC1 (Q2NKJ3) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7U5C chain E against the predicted model Q2NKJ3: TM-score 0.95, RMSD 2.60 Å
- 7U5C chain E against the predicted model Q2NKJ3: TM-score 0.95, RMSD 2.60 Å
- 6W6W chain A against the predicted model Q2NKJ3: TM-score 0.95, RMSD 2.51 Å
- 6W6W chain A against the predicted model Q2NKJ3: TM-score 0.95, RMSD 2.51 Å
- 8SOJ chain A against the predicted model Q2NKJ3: TM-score 0.95, RMSD 2.84 Å
- 8D0B chain A against the predicted model Q2NKJ3: TM-score 0.94, RMSD 2.79 Å
- 8D0B chain A against the predicted model Q2NKJ3: TM-score 0.94, RMSD 2.79 Å
- 5W2L chain A against the predicted model Q2NKJ3: TM-score 0.94, RMSD 1.09 Å
- 5W2L chain A against the predicted model Q2NKJ3: TM-score 0.94, RMSD 1.09 Å
- 8D0K chain A against the predicted model Q2NKJ3: TM-score 0.94, RMSD 2.91 Å
Elsewhere
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