UniProt Q29451
Lysosomal alpha-mannosidase (Q29451)
Lysosomal alpha-mannosidase (UniProt Q29451), EC 3.2.1.24: 2 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q29451
- Protein
- Lysosomal alpha-mannosidase
- EC
- 3.2.1.24
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 21 · 3 records with a druggable one
Structures
3 records of Q29451 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1O7D | The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low pH activation | x-ray diffraction | A, B, C, D, E | NAG, BMA, MAN, ZN, SO4 | 6 (best 0.82) |
| 1O7D | The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low pH activation | x-ray diffraction | A, B, C, D, E | NAG, BMA, MAN, ZN, SO4 | 6 (best 0.82) |
| Q29451 | AlphaFold monomer V2.0 prediction for lysosomal alpha-mannosidase (Q29451) | predicted | A | — | 9 (best 0.83) |
Ligands
Experiment against prediction
- 1O7D chain A against the predicted model Q29451: TM-score 1.00, RMSD 0.40 Å
- 1O7D chain A against the predicted model Q29451: TM-score 1.00, RMSD 0.40 Å
- 1O7D chain C against the predicted model Q29451: TM-score 0.99, RMSD 0.58 Å
- 1O7D chain C against the predicted model Q29451: TM-score 0.99, RMSD 0.58 Å
- 1O7D chain D against the predicted model Q29451: TM-score 0.98, RMSD 1.09 Å
- 1O7D chain D against the predicted model Q29451: TM-score 0.98, RMSD 1.09 Å
- 1O7D chain E against the predicted model Q29451: TM-score 0.97, RMSD 0.79 Å
- 1O7D chain E against the predicted model Q29451: TM-score 0.97, RMSD 0.79 Å
- 1O7D chain B against the predicted model Q29451: TM-score 0.97, RMSD 0.83 Å
- 1O7D chain B against the predicted model Q29451: TM-score 0.97, RMSD 0.83 Å
Elsewhere
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