UniProt Q28021
Rho-associated protein kinase 2 (Q28021)
Rho-associated protein kinase 2 (UniProt Q28021): 6 experimental structures and 1 predicted model on GenesisL1, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q28021
- Protein
- Rho-associated protein kinase 2
- Experimental structures
- 6
- Predicted models
- 1
- Pockets
- 10 · 1 record with a druggable one
Structures
7 records of Q28021 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1UIX | Coiled-coil structure of the RhoA-binding domain in Rho-kinase | x-ray diffraction | A, B | — | — |
| 1UIX | Coiled-coil structure of the rhoa-binding domain in rho- kinase | x-ray diffraction | A, B | — | — |
| 2F2U | crystal structure of the Rho-kinase kinase domain | x-ray diffraction | A, B | — | — |
| 2F2U | Crystal structure of the rho-kinase kinase domain | x-ray diffraction | A, B | — | — |
| 2H9V | Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y27632 | x-ray diffraction | A | — | — |
| 2H9V | Structural basis for induced-fit binding of rho-kinase to the inhibitor Y27632 | x-ray diffraction | A | — | — |
| Q28021 | AlphaFold monomer V2.0 prediction for rho-associated protein kinase 2 (Q28021) | predicted | A | — | 10 (best 0.67) |
Experiment against prediction
- 2F2U chain A against the predicted model Q28021: TM-score 0.99, RMSD 0.83 Å
- 2F2U chain A against the predicted model Q28021: TM-score 0.99, RMSD 0.83 Å
- 2H9V chain A against the predicted model Q28021: TM-score 0.98, RMSD 1.04 Å
- 2H9V chain A against the predicted model Q28021: TM-score 0.98, RMSD 1.04 Å
- 2F2U chain B against the predicted model Q28021: TM-score 0.98, RMSD 1.19 Å
- 2F2U chain B against the predicted model Q28021: TM-score 0.98, RMSD 1.19 Å
- 1UIX chain B against the predicted model Q28021: TM-score 0.91, RMSD 0.97 Å
- 1UIX chain B against the predicted model Q28021: TM-score 0.91, RMSD 0.97 Å
- 1UIX chain A against the predicted model Q28021: TM-score 0.86, RMSD 1.25 Å
- 1UIX chain A against the predicted model Q28021: TM-score 0.86, RMSD 1.25 Å
Elsewhere
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