UniProt Q27J81
Inverted formin-2 (Q27J81)
Inverted formin-2 (UniProt Q27J81): 8 experimental structures and 1 predicted model on GenesisL1, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q27J81
- Protein
- Inverted formin-2
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 27 · 6 records with a druggable one
Structures
9 records of Q27J81 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8RV2 | Structure of the formin INF2 bound to the barbed end of F-actin. | electron microscopy | E, F | — | 9 (best 0.72) |
| 9AZ4 | INF2 at the Barbed End of F-Actin | electron microscopy | G, H | — | 4 (best 0.76) |
| 9AZP | INF2 at the Barbed End of F-Actin with Incoming Profilin-Actin | electron microscopy | G, H | — | 5 (best 0.77) |
| 9AZQ | INF2 at the Barbed End of F-Actin with Incoming Actin | electron microscopy | G, H | — | 1 (best 0.67) |
| 9B03 | INF2 in the Middle of F-Actin (Up state) | electron microscopy | G, H | — | 4 (best 0.73) |
| 9B0K | INF2 in the Middle of F-Actin (Down state) | electron microscopy | G, H | — | 4 (best 0.73) |
| 9FJN | Solution NMR structure of a peptide encompassing residues 2-19 of the human formin INF2 | solution nmr | A | — | — |
| 9FJW | Solution NMR structure of a peptide encompassing residues 2-36 of the human formin INF2 | solution nmr | A | — | — |
| Q27J81 | AlphaFold monomer V2.0 prediction for inverted formin-2 (Q27J81) | predicted | A | — | — |
Experiment against prediction
- 9AZQ chain G against the predicted model Q27J81: TM-score 0.90, RMSD 0.90 Å
- 9AZQ chain H against the predicted model Q27J81: TM-score 0.90, RMSD 2.45 Å
- 9B03 chain G against the predicted model Q27J81: TM-score 0.79, RMSD 2.08 Å
- 9B0K chain G against the predicted model Q27J81: TM-score 0.79, RMSD 2.08 Å
- 9B03 chain H against the predicted model Q27J81: TM-score 0.79, RMSD 1.63 Å
- 9B0K chain H against the predicted model Q27J81: TM-score 0.79, RMSD 1.63 Å
- 8RV2 chain E against the predicted model Q27J81: TM-score 0.78, RMSD 2.80 Å
- 8RV2 chain F against the predicted model Q27J81: TM-score 0.78, RMSD 2.59 Å
- 9AZP chain H against the predicted model Q27J81: TM-score 0.77, RMSD 2.47 Å
- 9AZP chain G against the predicted model Q27J81: TM-score 0.76, RMSD 3.21 Å
Elsewhere
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