UniProt Q26454

DNA replication licensing factor MCM4 (Q26454)

DNA replication licensing factor MCM4 (UniProt Q26454), EC 3.6.4.12: 7 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction…

UniProt: Q26454
Protein: DNA replication licensing factor MCM4
EC: 3.6.4.12
Experimental structures: 7
Predicted models: 1
Ligands: 2
Pockets: 9 · 2 records with a druggable one

Structures

8 records of Q26454 in the MolNFT archive: 7 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6RAW	D. melanogaster cmg-DNA, state 1A	electron microscopy	4	ADP	—
6RAX	D. melanogaster CMG-DNA, State 1B	electron microscopy	4	ADP	—
6RAX	D. melanogaster cmg-DNA, state 1B	electron microscopy	4	ADP	—
6RAY	D. melanogaster CMG-DNA, State 2A	electron microscopy	4	ATP	5 (best 0.89)
6RAY	D. melanogaster cmg-DNA, state 2A	electron microscopy	4	ATP	—
6RAZ	D. melanogaster CMG-DNA, State 2B	electron microscopy	4	ATP	4 (best 0.89)
6RAZ	D. melanogaster cmg-DNA, state 2B	electron microscopy	4	ATP	—
Q26454	AlphaFold monomer V2.0 prediction for DNA replication licensing factor MCM4 (Q26454)	predicted	A	—	—

Ligands

ATP · Adenosine-5'-triphosphate · in 4 records
ADP · Adenosine-5'-diphosphate · in 3 records

Experiment against prediction

6RAZ chain 4 against the predicted model Q26454: TM-score 0.91, RMSD 2.74 Å
6RAZ chain 4 against the predicted model Q26454: TM-score 0.91, RMSD 2.74 Å
6RAY chain 4 against the predicted model Q26454: TM-score 0.91, RMSD 2.90 Å
6RAY chain 4 against the predicted model Q26454: TM-score 0.91, RMSD 2.90 Å
6RAW chain 4 against the predicted model Q26454: TM-score 0.78, RMSD 4.75 Å
6RAX chain 4 against the predicted model Q26454: TM-score 0.77, RMSD 4.84 Å
6RAX chain 4 against the predicted model Q26454: TM-score 0.77, RMSD 4.84 Å

Elsewhere

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