UniProt Q16850
Lanosterol 14-alpha demethylase (Q16850)
Lanosterol 14-alpha demethylase (UniProt Q16850), EC 1.14.13.70, 1.14.14.154: 16 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 35 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q16850
- Protein
- Lanosterol 14-alpha demethylase
- EC
- 1.14.13.70, 1.14.14.154
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 35 · 4 records with a druggable one
Structures
17 records of Q16850 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JUS | Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole | x-ray diffraction | A, B | — | — |
| 3JUS | Crystal structure of human lanosterol 14ALPHA-demethylase (CYP51) in complex with econazole | x-ray diffraction | A, B | — | — |
| 3JUV | Crystal structure of human lanosterol 14alpha-demethylase (CYP51) | x-ray diffraction | A | — | — |
| 3JUV | Crystal structure of human lanosterol 14ALPHA-demethylase (CYP51) | x-ray diffraction | A | — | — |
| 3LD6 | Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole | x-ray diffraction | A, B | — | — |
| 3LD6 | Crystal structure of human lanosterol 14ALPHA-demethylase (CYP51) in complex with ketoconazole | x-ray diffraction | A, B | — | — |
| 4UHI | Human sterol 14-alpha demethylase (CYP51) in complex with vfv in C121 space group | x-ray diffraction | A, B, C, D | — | — |
| 4UHI | Human sterol 14-alpha demethylase (CYP51) in complex with vfv in C121 space group | x-ray diffraction | A, B, C, D | — | — |
| 4UHL | Human sterol 14-alpha demethylase (CYP51) in complex with vfv in P1 space group | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4UHL | Human sterol 14-alpha demethylase (CYP51) in complex with vfv in P1 space group | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6Q2T | Human sterol 14a-demethylase (CYP51) in complex with the functionally irreversible inhibitor… | x-ray diffraction | A, B | HEM, PJM, DXC | 9 (best 0.85) |
| 6Q2T | Human sterol 14A-demethylase (CYP51) in complex with the functionally irreversible inhibitor… | x-ray diffraction | A, B | HEM, PJM, DXC | — |
| 6UEZ | Human sterol 14a-demethylase (CYP51) in complex with the substrate lanosterol | x-ray diffraction | A, B | HEM, LAN | 12 (best 0.87) |
| 6UEZ | Human sterol 14A-demethylase (CYP51) in complex with the substrate lanosterol | x-ray diffraction | A, B | HEM, LAN | — |
| 8SBI | Crystal structure of human sterol 14 alpha-demethylase (CYP51) in the ligand-free state | x-ray diffraction | A, B | HEM | 6 (best 0.85) |
| 8SS0 | Human sterol 14 alpha-demethylase (CYP51) in complex with the reaction intermediate 14… | x-ray diffraction | A, B | HEM, WQR | 8 (best 0.87) |
| Q16850 | AlphaFold monomer V2.0 prediction for lanosterol 14-alpha demethylase (Q16850) | predicted | A | — | — |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 6 records
- DXC · (3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oic acid · in 2 records
- LAN · Lanosterol · in 2 records
- PJM · N-[(1R)-1-(3-chloro-4'-fluoro[1,1'-biphenyl]-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-{5-[3-fluoro-5-(5-fluoropyrimidin-4-yl)phenyl]-1,3,4-oxadiazol-2-yl}benzamide · in 2 records
- WQR · 3beta-hydroxy-10alpha,13alpha-lanosta-8,24-dien-30-al · in 1 record
Experiment against prediction
- 3JUS chain A against the predicted model Q16850: TM-score 1.00, RMSD 0.51 Å
- 3JUS chain A against the predicted model Q16850: TM-score 1.00, RMSD 0.51 Å
- 3LD6 chain B against the predicted model Q16850: TM-score 1.00, RMSD 0.52 Å
- 3LD6 chain B against the predicted model Q16850: TM-score 1.00, RMSD 0.52 Å
- 3JUS chain B against the predicted model Q16850: TM-score 0.99, RMSD 0.55 Å
- 3JUS chain B against the predicted model Q16850: TM-score 0.99, RMSD 0.55 Å
- 3LD6 chain A against the predicted model Q16850: TM-score 0.99, RMSD 0.56 Å
- 3LD6 chain A against the predicted model Q16850: TM-score 0.99, RMSD 0.56 Å
- 6Q2T chain B against the predicted model Q16850: TM-score 0.99, RMSD 0.56 Å
- 6Q2T chain B against the predicted model Q16850: TM-score 0.99, RMSD 0.56 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.