UniProt Q16778
Histone H2B type 2-E (Q16778)
Histone H2B type 2-E (UniProt Q16778), EC 2.3.2.23, 2.3.2.24: 25 experimental structures on GenesisL1, 3 ligands bound, 144 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q16778
- Protein
- Histone H2B type 2-E
- EC
- 2.3.2.23, 2.3.2.24, 2.3.2.27
- Experimental structures
- 25
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 144 · 15 records with a druggable one
Structures
25 records of Q16778 in the MolNFT archive: 25 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4NFT | Crystal structure of human lnkH2B-h2A.Z-Anp32e | x-ray diffraction | A, B, C, D | — | — |
| 4NFT | Crystal structure of human LNKH2B-H2A.Z-ANP32E | x-ray diffraction | A, B, C, D | — | — |
| 6A7U | Crystal structure of histone H2A.BBD-H2B dimer | x-ray diffraction | A | — | — |
| 6KBB | Role of the DEF/Y motif of SWC5 in histone H2A.Z deposition | x-ray diffraction | D, B | — | — |
| 6M4D | Structural mechanism of nucleosome dynamics governed by human histone variants H2A.B and H2A.Z.2.2 | electron microscopy | D, H | — | — |
| 6M4G | Structural mechanism of nucleosome dynamics governed by human histone variants H2A.B and H2A.Z.2.2 | electron microscopy | D, H | — | 8 (best 0.78) |
| 6M4G | Structural mechanism of nucleosome dynamics governed by human histone variants H2A.B and H2A.Z.2.2 | electron microscopy | D, H | — | — |
| 6M4H | Structural mechanism of nucleosome dynamics governed by human histone variants H2A.B and H2A.Z.2.2 | electron microscopy | D, H | — | — |
| 7BXT | The cryo-EM structure of CENP-A nucleosome in complex with CENP-C peptide and CENP-N N-terminal… | electron microscopy | D, H | — | 11 (best 0.87) |
| 7BXT | The cryo-EM structure of cenp-a nucleosome in complex with cenp-C peptide and cenp-N N-terminal… | electron microscopy | D, H | — | — |
| 7EA8 | Human SETD2 bound to a nucleosome containing oncohistone mutations | electron microscopy | D, H | — | — |
| 7U0G | structure of LIN28b nucleosome bound 3 OCT4 | electron microscopy | D, H | — | 12 (best 0.80) |
| 7U0I | Structure of LIN28b nucleosome bound 2 OCT4 | electron microscopy | D, H | — | 14 (best 0.81) |
| 8DK5 | Structure of 187bp LIN28b nucleosome with site 0 mutation | electron microscopy | D, H | — | 12 (best 0.82) |
| 8EVH | CX3CR1 nucleosome and wild type PU.1 complex | electron microscopy | D, H | — | 13 (best 0.78) |
| 8EVI | CX3CR1 nucleosome and PU.1 complex containing disulfide bond mutations | electron microscopy | D, H | — | 13 (best 0.75) |
| 8H1T | Cryo-EM structure of BAP1-ASXL1 bound to chromatosome | electron microscopy | D, H | — | 9 (best 0.82) |
| 8SPS | High resolution structure of ESRRB nucleosome bound OCT4 at site a and site b | electron microscopy | D, H | — | 11 (best 0.82) |
| 8SPU | Structure of ESRRB nucleosome bound OCT4 at site c | electron microscopy | H, D | — | 10 (best 0.82) |
| 8SYP | Genomic CX3CR1 nucleosome | electron microscopy | D, H | — | 14 (best 0.78) |
| 8UQ9 | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 4-residue linker | x-ray diffraction | A, a | CL, ZN, NA | 7 (best 0.74) |
| 8UQA | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 12-residue linker | x-ray diffraction | K | NA, ZN, CL | 3 (best 0.52) |
| 8UQB | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization… | x-ray diffraction | A | ZN, CL | 3 (best 0.53) |
| 8UQC | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization… | x-ray diffraction | A | ZN | 4 (best 0.55) |
| Q16778 | AlphaFold monomer V2.0 prediction for histone H2B type 2-E (Q16778) | — | — | — |
Ligands
Experiment against prediction
- 8UQ9 chain A against the predicted model P04908: TM-score 0.22, RMSD 2.05 Å
- 6A7U chain A against the predicted model P0C5Z0: TM-score 0.47, RMSD 1.19 Å
- 8UQ9 chain a against the predicted model P04908: TM-score 0.22, RMSD 2.05 Å
- 8UQB chain A against the predicted model P04908: TM-score 0.22, RMSD 0.90 Å
- 8UQC chain A against the predicted model P04908: TM-score 0.21, RMSD 0.93 Å
- 8UQA chain K against the predicted model P04908: TM-score 0.21, RMSD 0.93 Å
- 4NFT chain A against the predicted model P0C0S5: TM-score 0.46, RMSD 1.31 Å
- 4NFT chain A against the predicted model P0C0S5: TM-score 0.46, RMSD 1.31 Å
- 4NFT chain C against the predicted model P0C0S5: TM-score 0.47, RMSD 1.63 Å
- 4NFT chain C against the predicted model P0C0S5: TM-score 0.47, RMSD 1.63 Å
Elsewhere
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