UniProt Q16769
Glutaminyl-peptide cyclotransferase (Q16769)
Glutaminyl-peptide cyclotransferase (UniProt Q16769), EC 2.3.2.5: 60 experimental structures on GenesisL1, 14 ligands bound, 97 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q16769
- Protein
- Glutaminyl-peptide cyclotransferase
- EC
- 2.3.2.5
- Experimental structures
- 60
- Predicted models
- 0
- Ligands
- 14
- Pockets
- 97 · 9 records with a druggable one
Structures
60 records of Q16769 in the MolNFT archive: 60 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AFM | Crystal structure of human glutaminyl cyclase at pH 6.5 | x-ray diffraction | A, B | — | — |
| 2AFM | Crystal structure of human glutaminyl cyclase at pH 6.5 | x-ray diffraction | A, B | — | — |
| 2AFO | Crystal structure of human glutaminyl cyclase at pH 8.0 | x-ray diffraction | A, B | — | — |
| 2AFO | Crystal structure of human glutaminyl cyclase at pH 8.0 | x-ray diffraction | A, B | — | — |
| 2AFS | Crystal structure of the genetic mutant R54W of human glutaminyl cyclase | x-ray diffraction | A, B | — | — |
| 2AFS | Crystal structure of the genetic mutant R54W of human glutaminyl cyclase | x-ray diffraction | A, B | — | — |
| 2AFU | Crystal structure of human glutaminyl cyclase in complex with glutamine t-butyl ester | x-ray diffraction | A, B | — | — |
| 2AFU | Crystal structure of human glutaminyl cyclase in complex with glutamine T-butyl ester | x-ray diffraction | A, B | — | — |
| 2AFW | Crystal structure of human glutaminyl cyclase in complex with N-acetylhistamine | x-ray diffraction | A, B | — | — |
| 2AFW | Crystal structure of human glutaminyl cyclase in complex with N- acetylhistamine | x-ray diffraction | A, B | — | — |
| 2AFX | Crystal structure of human glutaminyl cyclase in complex with 1-benzylimidazole | x-ray diffraction | A, B | — | — |
| 2AFX | Crystal structure of human glutaminyl cyclase in complex with 1- benzylimidazole | x-ray diffraction | A, B | — | — |
| 2AFZ | Crystal structure of human glutaminyl cyclase in complex with 1-vinylimidazole | x-ray diffraction | A, B | — | — |
| 2AFZ | Crystal structure of human glutaminyl cyclase in complex with 1- vinylimidazole | x-ray diffraction | A, B | — | — |
| 2ZED | Crystal structure of the human glutaminyl cyclase mutant S160A at 1.7 angstrom resolution | x-ray diffraction | A, B | — | — |
| 2ZED | Crystal structure of the human glutaminyl cyclase mutant S160A at 1.7 ångström resolution | x-ray diffraction | A, B | — | — |
| 2ZEE | Crystal structure of the human glutaminyl cyclase mutant S160G at 1.99 angstrom resolution | x-ray diffraction | A, B | — | — |
| 2ZEE | Crystal structure of the human glutaminyl cyclase mutant S160G at 1.99 ångström resolution | x-ray diffraction | A, B | — | — |
| 2ZEF | Crystal structure of the human glutaminyl cyclase mutant E201D at 1.67 angstrom resolution | x-ray diffraction | A, B | — | — |
| 2ZEF | Crystal structure of the human glutaminyl cyclase mutant E201D at 1.67 ångström resolution | x-ray diffraction | A, B | — | — |
| 2ZEG | Crystal structure of the human glutaminyl cyclase mutant E201L at 2.08 angstrom resolution | x-ray diffraction | A, B | — | — |
| 2ZEG | Crystal structure of the human glutaminyl cyclase mutant E201L at 2.08 ångström resolution | x-ray diffraction | A, B | — | — |
| 2ZEH | Crystal structure of the human glutaminyl cyclase mutant E201Q at 1.8 angstrom resolution | x-ray diffraction | A, B | — | — |
| 2ZEH | Crystal structure of the human glutaminyl cyclase mutant E201Q at 1.8 ångström resolution | x-ray diffraction | A, B | — | — |
| 2ZEL | Crystal structure of the human glutaminyl cyclase mutant D248A at 1.97 angstrom resolution | x-ray diffraction | A, B | — | — |
| 2ZEL | Crystal structure of the human glutaminyl cyclase mutant D248A at 1.97 ångström resolution | x-ray diffraction | A, B | — | — |
| 2ZEM | Crystal structure of the human glutaminyl cyclase mutant D248Q at 2.18 angstrom resolution | x-ray diffraction | A, B | — | — |
| 2ZEM | Crystal structure of the human glutaminyl cyclase mutant D248Q at 2.18 ångström resolution | x-ray diffraction | A, B | — | — |
| 2ZEN | Crystal structure of the human glutaminyl cyclase mutant D305A at 1.78 angstrom resolution | x-ray diffraction | A, B | — | — |
| 2ZEN | Crystal structure of the human glutaminyl cyclase mutant D305A at 1.78 ångström resolution | x-ray diffraction | A, B | — | — |
| 2ZEO | Crystal structure of the human glutaminyl cyclase mutant D305E at 1.66 angstrom resolution | x-ray diffraction | A, B | — | — |
| 2ZEO | Crystal structure of the human glutaminyl cyclase mutant D305E at 1.66 ångström resolution | x-ray diffraction | A, B | — | — |
| 2ZEP | Crystal structure of the human glutaminyl cyclase mutant H319L at 2.1 angstrom resolution | x-ray diffraction | A, B | — | — |
| 2ZEP | Crystal structure of the human glutaminyl cyclase mutant H319L at 2.1 ångström resolution | x-ray diffraction | A, B | — | — |
| 3PBB | Crystal structure of human secretory glutaminyl cyclase in complex with PBD150 | x-ray diffraction | A, B | — | — |
| 3PBB | Crystal structure of human secretory glutaminyl cyclase in complex with PBD150 | x-ray diffraction | A, B | — | — |
| 3PBE | Crystal structure of the mutant W207F of human secretory glutaminyl cyclase | x-ray diffraction | A, B | — | — |
| 3PBE | Crystal structure of the mutant W207F of human secretory glutaminyl cyclase | x-ray diffraction | A, B | — | — |
| 3SI0 | Structure of glycosylated human glutaminyl cyclase | x-ray diffraction | A | — | — |
| 3SI0 | Structure of glycosylated human glutaminyl cyclase | x-ray diffraction | A | — | — |
| 4YU9 | Crystal Structure of double mutant Y115E Y117E human Glutaminyl Cyclase | x-ray diffraction | A, B, C | — | — |
| 4YU9 | Crystal structure of double mutant Y115E Y117E human glutaminyl cyclase | x-ray diffraction | A, B, C | — | — |
| 4YWY | Crystal Structure of double mutant Y115E Y117E human Glutaminyl Cyclase in complex with inhibitor… | x-ray diffraction | A, B, C | ZN, PBD, SO4, CL | 11 (best 0.72) |
| 4YWY | Crystal structure of double mutant Y115E Y117E human glutaminyl cyclase in complex with inhibitor… | x-ray diffraction | A, B, C | — | — |
| 6GBX | Crystal structure of human glutaminyl cyclase variant Y115E-Y117E in complex with SEN177 | x-ray diffraction | A, B, C | ZN, SO4, S77 | — |
| 6YI1 | Crystal structure of human glutaminyl cyclase in complex with GLU(GAMMA-hydrazide)-phe-ala | x-ray diffraction | A, B | SO4, ZN, ORT, 66N | — |
| 6YJY | Crystal structure of human glutaminyl cyclase in complex with neurotensin 1-5 | x-ray diffraction | A, B | SO4, ZN | — |
| 7CM0 | Crystal structure of a glutaminyl cyclase in complex with nhv-1009 | x-ray diffraction | A, B, C, D | G5R, ZN | — |
| 7COZ | Crystal structure of double mutant Y115E Y117E human secretory glutaminyl cyclase in complex with… | — | — | — | |
| 7CP0 | Crystal structure of double mutant Y115E Y117E human secretory glutaminyl cyclase | x-ray diffraction | A, B, C | ZN, SO4 | — |
| 7D8E | Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase in complex with… | x-ray diffraction | A, B, C | ZN, SO4, GYO | 10 (best 0.79) |
| 7D8E | Crystal structure of double mutant Y115E Y117E human secretory glutaminyl cyclase in complex with… | — | — | — | |
| 8HY3 | Crystal structure of human secretory glutaminyl cyclase in complex with… | x-ray diffraction | A | ZN, 4Q8, CO2 | 2 (best 0.52) |
| 8XGT | Crystal structure of human secretory glutaminyl cyclase in complex with… | x-ray diffraction | B, A, C, D, E, F, G, H, I, J, K, L | ZN, A1D48 | 20 (best 0.85) |
| 8XGY | Crystal structure of human Golgi resident glutaminyl cyclase in complex with… | x-ray diffraction | B, A, C, D, E, F, G, H, I, J, K, L | ZN, A1D5C | 20 (best 0.86) |
| 9FXG | Crystal structure of double mutant Y115E Y117E human Glutaminyl Cyclase in apo-state | x-ray diffraction | A, B, C | SO4 | 9 (best 0.73) |
| 9FXH | Crystal structure of cobalt(II)-substituted double mutant Y115E Y117E human Glutaminyl Cyclase | x-ray diffraction | A, B, C | CO, SO4 | 8 (best 0.72) |
| 9FXI | Crystal structure of cobalt(II)-substituted double mutant Y115E Y117E human Glutaminyl Cyclase in… | x-ray diffraction | A, B, C | CO, S77, SO4 | 9 (best 0.71) |
| 9FXJ | Crystal structure of cobalt(II)-substituted double mutant Y115E Y117E human Glutaminyl Cyclase in… | x-ray diffraction | A, B, C | CO, PBD, SO4 | 8 (best 0.71) |
| Q16769 | AlphaFold monomer V2.0 prediction for glutaminyl-peptide cyclotransferase (Q16769) | — | — | — |
Ligands
- SO4 · Sulfate ion · in 10 records
- ZN · Zinc ion · in 10 records
- CO · Cobalt (II) ion · in 3 records
- PBD · 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea · in 2 records
- S77 · 2-fluoranyl-5-[2-[4-(4-methyl-1,2,4-triazol-3-yl) piperidin-1-yl]pyridin-3-yl]pyridine · in 2 records
- 4Q8 · 5-methyl-1-(phenylmethyl)imidazole · in 1 record
- 66N · L-alaninamide · in 1 record
- A1D48 · (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-oxidanyl-1~{H}-indol-2-one · in 1 record
- A1D5C · (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-[(3~{R})-1-ethanoylpyrrolidin-3-yl]oxy-1~{H}-indol-2-one · in 1 record
- CL · Chloride ion · in 1 record
- CO2 · Carbon dioxide · in 1 record
- G5R · 1-(cyclopentylmethyl)-1-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl) propyl]urea · in 1 record
- GYO · ~{N}-[(1~{S},2~{S})-2-(2-methoxyphenyl)cyclopropyl]-3~{H}-benzimidazole-5-carboxamide · in 1 record
- ORT · (4~{S})-4-azanyl-5-oxidanylidene-pentanehydrazide · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.