UniProt Q16595
Frataxin mature form (Q16595)
Frataxin mature form (UniProt Q16595): 28 experimental structures and 1 predicted model on GenesisL1, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q16595
- Protein
- Frataxin mature form
- Experimental structures
- 28
- Predicted models
- 1
- Pockets
- 12 · 3 records with a druggable one
Structures
29 records of Q16595 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EKG | Mature human frataxin | x-ray diffraction | A | — | — |
| 1EKG | Mature human frataxin | x-ray diffraction | A | — | — |
| 1LY7 | The solution structure of the the c-terminal domain of frataxin, the protein responsible for… | solution nmr | A | — | — |
| 1LY7 | The solution structure of the the C-terminal domain of frataxin, the protein responsible for… | solution nmr | A | — | — |
| 3S4M | Crystal structure of wild-type human frataxin | x-ray diffraction | A | — | — |
| 3S4M | Crystal structure of wild-type human frataxin | x-ray diffraction | A | — | — |
| 3S5D | Crystal structure of human frataxin variant W155A | x-ray diffraction | A | — | — |
| 3S5D | Crystal structure of human frataxin variant W155A | x-ray diffraction | A | — | — |
| 3S5E | Crystal structure of human frataxin variant W155R, one of the Friedreich's ataxia point mutations | x-ray diffraction | A | — | — |
| 3S5E | Crystal structure of human frataxin variant W155R, one of the FRIEDREICH'S ataxia point mutations | x-ray diffraction | A | — | — |
| 3S5F | Crystal structure of human frataxin variant W155F | x-ray diffraction | A, B | — | — |
| 3S5F | Crystal structure of human frataxin variant W155F | x-ray diffraction | A, B | — | — |
| 3T3J | 1.70 A structure of Friedreich's ataxia frataxin variant N146K | x-ray diffraction | A | — | — |
| 3T3J | 1.70 a structure of FRIEDREICH'S ataxia frataxin variant N146K | x-ray diffraction | A | — | — |
| 3T3K | 1.24 A Structure of Friedreich's ataxia frataxin variant Q148R | x-ray diffraction | A | — | — |
| 3T3K | 1.24 a structure of FRIEDREICH'S ataxia frataxin variant Q148R | x-ray diffraction | A | — | — |
| 3T3L | 1.15 A structure of human frataxin variant Q153A | x-ray diffraction | A | — | — |
| 3T3L | 1.15 a structure of human frataxin variant Q153A | x-ray diffraction | A | — | — |
| 3T3T | 1.38 A structure of human frataxin variant Q148G | x-ray diffraction | A, B, C, D | — | — |
| 3T3T | 1.38 a structure of human frataxin variant Q148G | x-ray diffraction | A, B, C, D | — | — |
| 3T3X | 1.57 A structure of Friedreich's ataxia frataxin variant R165C | x-ray diffraction | A, B | — | — |
| 3T3X | 1.57 a structure of FRIEDREICH'S ataxia frataxin variant R165C | x-ray diffraction | A, B | — | — |
| 5KZ5 | Architecture of the human mitochondrial iron-sulfur cluster assembly machinery: the complex formed… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 6NZU | Structure of the human frataxin-bound iron-sulfur cluster assembly complex | electron microscopy | I, J | — | — |
| 6NZU | Structure of the human frataxin-bound iron-sulfur cluster assembly complex | electron microscopy | I, J | — | — |
| 8PK8 | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | E | — | 3 (best 0.73) |
| 8PK9 | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | E | — | 3 (best 0.65) |
| 8RME | Structure of the core ISC complex under turnover conditions (frataxin-bound) | electron microscopy | I | — | 6 (best 0.78) |
| Q16595 | AlphaFold monomer V2.0 prediction for frataxin, mitochondrial (Q16595) | predicted | A | — | — |
Experiment against prediction
- 1EKG chain A against the predicted model Q16595: TM-score 0.99, RMSD 0.34 Å
- 1EKG chain A against the predicted model Q16595: TM-score 0.99, RMSD 0.34 Å
- 8RME chain I against the predicted model Q16595: TM-score 0.99, RMSD 0.39 Å
- 3S5D chain A against the predicted model Q16595: TM-score 0.99, RMSD 0.41 Å
- 3S5D chain A against the predicted model Q16595: TM-score 0.99, RMSD 0.41 Å
- 8PK9 chain E against the predicted model Q16595: TM-score 0.99, RMSD 0.42 Å
- 3T3T chain A against the predicted model Q16595: TM-score 0.99, RMSD 0.42 Å
- 3T3T chain A against the predicted model Q16595: TM-score 0.99, RMSD 0.42 Å
- 3T3T chain C against the predicted model Q16595: TM-score 0.99, RMSD 0.42 Å
- 3T3T chain C against the predicted model Q16595: TM-score 0.99, RMSD 0.42 Å
Elsewhere
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