UniProt Q16584
Mitogen-activated protein kinase kinase kinase 11 (Q16584)
Mitogen-activated protein kinase kinase kinase 11 (UniProt Q16584), EC 2.7.11.25: 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 4 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q16584
- Protein
- Mitogen-activated protein kinase kinase kinase 11
- EC
- 2.7.11.25
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 4 · 2 records with a druggable one
Structures
9 records of Q16584 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5K26 | Structure of the SH3 domain of MLK3 bound to peptide generated from phage display | x-ray diffraction | A, B | — | 1 (best 0.65) |
| 5K26 | Structure of the SH3 domain of MLK3 bound to peptide generated from phage display | x-ray diffraction | A, B | — | — |
| 5K28 | Structure of the unbound SH3 domain of MLK3 | x-ray diffraction | A, B | — | — |
| 5K28 | Structure of the unbound SH3 domain of MLK3 | x-ray diffraction | A, B | — | — |
| 6AQB | Structure of the SH3 domain of MLK3 bound to peptide generated from phage display | x-ray diffraction | A, B | PO4 | — |
| 6AQB | Structure of the SH3 domain of MLK3 bound to peptide generated from phage display | x-ray diffraction | A, B | PO4 | — |
| 6CQ7 | The SH3 domain of MLK3 in complex with poly-proline peptide derived from Htt | x-ray diffraction | A | — | — |
| 6CQ7 | The SH3 domain of MLK3 in complex with poly-proline peptide derived from htt | x-ray diffraction | A | — | — |
| Q16584 | AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase kinase kinase 11 (Q16584) | predicted | A | — | 3 (best 0.80) |
Ligands
- PO4 · Phosphate ion · in 2 records
Experiment against prediction
- 5K28 chain A against the predicted model Q16584: TM-score 0.91, RMSD 1.03 Å
- 5K28 chain A against the predicted model Q16584: TM-score 0.91, RMSD 1.03 Å
- 6CQ7 chain A against the predicted model Q16584: TM-score 0.89, RMSD 1.73 Å
- 6CQ7 chain A against the predicted model Q16584: TM-score 0.89, RMSD 1.73 Å
- 6AQB chain A against the predicted model Q16584: TM-score 0.83, RMSD 1.02 Å
- 6AQB chain A against the predicted model Q16584: TM-score 0.83, RMSD 1.02 Å
- 5K26 chain A against the predicted model Q16584: TM-score 0.78, RMSD 2.36 Å
- 5K26 chain A against the predicted model Q16584: TM-score 0.78, RMSD 2.36 Å
- 5K26 chain B against the predicted model Q16584: TM-score 0.73, RMSD 1.90 Å
- 5K26 chain B against the predicted model Q16584: TM-score 0.73, RMSD 1.90 Å
Elsewhere
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