UniProt Q16281
Cyclic nucleotide-gated cation channel alpha-3 (Q16281)
Cyclic nucleotide-gated cation channel alpha-3 (UniProt Q16281): 9 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 96 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q16281
- Protein
- Cyclic nucleotide-gated cation channel alpha-3
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 96 · 5 records with a druggable one
Structures
10 records of Q16281 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3SWY | CNGA3 626-672 containing CLZ domain | x-ray diffraction | A, B, C | — | — |
| 3SWY | CNGA3 626-672 containing clz domain | x-ray diffraction | A, B, C | — | — |
| 7RHS | Cryo-EM structure of apo-state of human CNGA3/CNGB3 channel | electron microscopy | A, B, C | NAG, NA | — |
| 8ETP | Cryo-EM structure of cGMP bound closed state of human CNGA3/CNGB3 channel in GDN | electron microscopy | A, B, C | NAG, PCG | 20 (best 0.77) |
| 8EU3 | Cryo-EM structure of cGMP bound human CNGA3/CNGB3 channel in GDN, transition state 1 | electron microscopy | A, B, C | NAG, PCG | — |
| 8EUC | Cryo-EM structure of cGMP bound human CNGA3/CNGB3 channel in GDN, transition state 2 | electron microscopy | A, B, C | NAG, PCG | 19 (best 0.79) |
| 8EV8 | Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, closed state | electron microscopy | A, B, C | NAG, PCG | 18 (best 0.80) |
| 8EV9 | Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, transition… | electron microscopy | A, B, C | NAG, PCG | 19 (best 0.77) |
| 8EVA | Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, transition… | electron microscopy | A, B, C | NAG, PCG | 20 (best 0.79) |
| Q16281 | AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated cation channel alpha-3 (Q16281) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8EU3 chain B against the predicted model Q16281: TM-score 0.96, RMSD 1.57 Å
- 8EUC chain B against the predicted model Q16281: TM-score 0.96, RMSD 1.60 Å
- 8EVA chain B against the predicted model Q16281: TM-score 0.96, RMSD 1.67 Å
- 8EVA chain C against the predicted model Q16281: TM-score 0.95, RMSD 1.73 Å
- 8EU3 chain A against the predicted model Q16281: TM-score 0.95, RMSD 1.81 Å
- 8EV9 chain A against the predicted model Q16281: TM-score 0.95, RMSD 1.62 Å
- 8EV9 chain C against the predicted model Q16281: TM-score 0.95, RMSD 1.68 Å
- 8EUC chain C against the predicted model Q16281: TM-score 0.95, RMSD 1.82 Å
- 8EV9 chain B against the predicted model Q16281: TM-score 0.95, RMSD 1.67 Å
- 8EVA chain A against the predicted model Q16281: TM-score 0.95, RMSD 1.83 Å
Elsewhere
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