UniProt Q15822

Neuronal acetylcholine receptor subunit alpha-2 (Q15822)

Neuronal acetylcholine receptor subunit alpha-2 (UniProt Q15822): 2 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: Q15822
Protein: Neuronal acetylcholine receptor subunit alpha-2
Experimental structures: 2
Predicted models: 1
Ligands: 1
Pockets: 20 · 1 record with a druggable one

Structures

3 records of Q15822 in the MolNFT archive: 2 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5FJV	Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in…	x-ray diffraction	A, B, C, D, E	EPJ	20 (best 0.75)
5FJV	Crystal structure of the extracellular domain of ALPHA2 nicotinic acetylcholine receptor in…	x-ray diffraction	A, B, C, D, E	—	—
Q15822	AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit alpha-2 (Q15822)	predicted	A	—	—

Ligands

EPJ · Epibatidine · in 1 record

Experiment against prediction

5FJV chain A against the predicted model Q15822: TM-score 0.95, RMSD 1.25 Å
5FJV chain A against the predicted model Q15822: TM-score 0.95, RMSD 1.25 Å
5FJV chain D against the predicted model Q15822: TM-score 0.95, RMSD 1.36 Å
5FJV chain D against the predicted model Q15822: TM-score 0.95, RMSD 1.36 Å
5FJV chain E against the predicted model Q15822: TM-score 0.95, RMSD 1.45 Å
5FJV chain E against the predicted model Q15822: TM-score 0.95, RMSD 1.45 Å
5FJV chain B against the predicted model Q15822: TM-score 0.94, RMSD 1.44 Å
5FJV chain B against the predicted model Q15822: TM-score 0.94, RMSD 1.44 Å
5FJV chain C against the predicted model Q15822: TM-score 0.93, RMSD 1.86 Å
5FJV chain C against the predicted model Q15822: TM-score 0.93, RMSD 1.86 Å

Elsewhere

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