UniProt Q15528
Mediator of RNA polymerase II transcription subunit 22 (Q15528)
Mediator of RNA polymerase II transcription subunit 22 (UniProt Q15528): 7 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15528
- Protein
- Mediator of RNA polymerase II transcription subunit 22
- Experimental structures
- 7
- Predicted models
- 1
- Pockets
- 3 · 1 record with a druggable one
Structures
8 records of Q15528 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | V | — | 3 (best 0.80) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | V | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | v | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | v | — | — |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | V | — | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | g | — | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | g | — | — |
| Q15528 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 22… | predicted | A | — | — |
Experiment against prediction
- 7ENC chain v against the predicted model Q15528: TM-score 0.66, RMSD 3.69 Å
- 7NVR chain g against the predicted model Q15528: TM-score 0.66, RMSD 3.65 Å
- 7NVR chain g against the predicted model Q15528: TM-score 0.66, RMSD 3.65 Å
- 7EMF chain V against the predicted model Q15528: TM-score 0.64, RMSD 3.71 Å
- 7EMF chain V against the predicted model Q15528: TM-score 0.64, RMSD 3.71 Å
- 7ENJ chain V against the predicted model Q15528: TM-score 0.64, RMSD 3.71 Å
- 7ENA chain v against the predicted model Q15528: TM-score 0.62, RMSD 3.73 Å
Elsewhere
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