UniProt Q15172
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (Q15172)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (UniProt Q15172): 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 13 pockets. Binding sites, druggability and…
- UniProt
- Q15172
- Protein
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 13 · 2 records with a druggable one
Structures
4 records of Q15172 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6NTS | Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule… | electron microscopy | B | L2J | 6 (best 0.76) |
| 6NTS | Protein phosphatase 2A (aalpha-B56ALPHA-calpha) holoenzyme in complex with a small molecule… | electron microscopy | B | L2J | — |
| 8SZK | The cryo-EM structure of PPP2R5A/HIV-1 Vif/CBFb/EloB/EloC complex | electron microscopy | D | — | 7 (best 0.75) |
| Q15172 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory… | predicted | A | — | — |
Ligands
- L2J · N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl) cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide · in 2 records
Experiment against prediction
- 6NTS chain B against the predicted model Q15172: TM-score 0.96, RMSD 1.47 Å
- 6NTS chain B against the predicted model Q15172: TM-score 0.96, RMSD 1.47 Å
- 8SZK chain D against the predicted model Q15172: TM-score 0.94, RMSD 1.80 Å
Elsewhere
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