UniProt Q15125
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Q15125)
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (UniProt Q15125), EC 5.3.3.5: 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 23 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q15125
- Protein
- 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
- EC
- 5.3.3.5
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 23 · 3 records with a druggable one
Structures
7 records of Q15125 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6OHT | Structure of EBP and U18666A | x-ray diffraction | A, B, C | MKM | — |
| 6OHT | Structure of ebp and U18666A | x-ray diffraction | A, B, C | MKM | — |
| 6OHU | Structure of EBP and tamoxifen | x-ray diffraction | A, B, C | CTX | 9 (best 0.81) |
| 6OHU | Structure of ebp and tamoxifen | x-ray diffraction | A, B, C | CTX | — |
| 8W0R | Human EBP complexed with compound 1 | electron microscopy | A, B | A1AEU | 7 (best 0.80) |
| 8W0S | Human EBP complexed with compound 3a | electron microscopy | A, B | A1AEV | 7 (best 0.76) |
| Q15125 | AlphaFold monomer V2.0 prediction for 3-beta-hydroxysteroid- DELTA(8),DELTA(7)-isomerase (Q15125) | predicted | A | — | — |
Ligands
- CTX · (Z)-2-[4-(1,2)-diphenyl-1-butenyl)-phenoxy]-N,N-dimethylethanamine · in 2 records
- MKM · 3beta-(2-Diethylaminoethoxy)androst-5-en-17-one · in 2 records
- A1AEU · 1-methyl-1'-[(oxan-4-yl)methyl]-5-(trifluoromethyl)spiro[indole-2,4'-piperidin]-3(1H)-one · in 1 record
- A1AEV · 1-methyl-8-[(oxan-4-yl)methyl]-3-[4-(trifluoromethyl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione · in 1 record
Experiment against prediction
- 8W0R chain B against the predicted model Q15125: TM-score 0.99, RMSD 0.71 Å
- 8W0R chain A against the predicted model Q15125: TM-score 0.99, RMSD 0.71 Å
- 8W0S chain A against the predicted model Q15125: TM-score 0.98, RMSD 0.78 Å
- 8W0S chain B against the predicted model Q15125: TM-score 0.98, RMSD 0.79 Å
- 6OHU chain C against the predicted model Q15125: TM-score 0.97, RMSD 0.97 Å
- 6OHU chain C against the predicted model Q15125: TM-score 0.97, RMSD 0.97 Å
- 6OHT chain C against the predicted model Q15125: TM-score 0.97, RMSD 1.07 Å
- 6OHT chain C against the predicted model Q15125: TM-score 0.97, RMSD 1.07 Å
- 6OHT chain A against the predicted model Q15125: TM-score 0.97, RMSD 1.13 Å
- 6OHT chain A against the predicted model Q15125: TM-score 0.97, RMSD 1.13 Å
Elsewhere
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