UniProt Q15118
[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Q15118)
[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (UniProt Q15118): 6 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q15118
- Protein
- [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
- Experimental structures
- 6
- Predicted models
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
7 records of Q15118 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2Q8F | Structure of pyruvate dehydrogenase kinase isoform 1 | x-ray diffraction | A | — | — |
| 2Q8F | Structure of pyruvate dehydrogenase kinase isoform 1 | x-ray diffraction | A | — | — |
| 2Q8G | Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545 | x-ray diffraction | A | — | — |
| 2Q8G | Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545 | x-ray diffraction | A | — | — |
| 2Q8H | Structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (DCA) | x-ray diffraction | A | — | — |
| 2Q8H | Structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (dca) | x-ray diffraction | A | — | — |
| Q15118 | AlphaFold monomer V2.0 prediction for [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme… | predicted | A | — | 6 (best 0.72) |
Experiment against prediction
- 2Q8F chain A against the predicted model Q15118: TM-score 0.97, RMSD 1.29 Å
- 2Q8F chain A against the predicted model Q15118: TM-score 0.97, RMSD 1.29 Å
- 2Q8H chain A against the predicted model Q15118: TM-score 0.97, RMSD 1.32 Å
- 2Q8H chain A against the predicted model Q15118: TM-score 0.97, RMSD 1.32 Å
- 2Q8G chain A against the predicted model Q15118: TM-score 0.97, RMSD 1.32 Å
- 2Q8G chain A against the predicted model Q15118: TM-score 0.97, RMSD 1.32 Å
Elsewhere
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