UniProt Q15078
Cyclin-dependent kinase 5 activator 1, p25 (Q15078)
Cyclin-dependent kinase 5 activator 1, p25 (UniProt Q15078): 19 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q15078
- Protein
- Cyclin-dependent kinase 5 activator 1, p25
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 9 · 2 records with a druggable one
Structures
20 records of Q15078 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1H4L | Structure and regulation of the CDK5-p25(nck5a) complex | x-ray diffraction | D, E | — | — |
| 1H4L | Structure and regulation of the CDK5-P25(NCK5A) complex | x-ray diffraction | D, E | — | — |
| 1UNG | Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin. | x-ray diffraction | D, E | — | — |
| 1UNG | Structural mechanism for the inhibition of CDK5-P25 by roscovitine, aloisine and indirubin. | x-ray diffraction | D, E | — | — |
| 1UNH | Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin. | x-ray diffraction | D, E | — | — |
| 1UNH | Structural mechanism for the inhibition of CDK5-P25 by roscovitine, aloisine and indirubin. | x-ray diffraction | D, E | — | — |
| 1UNL | Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin. | x-ray diffraction | D, E | — | — |
| 1UNL | Structural mechanism for the inhibition of CD5-P25 from the roscovitine, aloisine and indirubin. | x-ray diffraction | D, E | — | — |
| 3O0G | Crystal Structure of Cdk5:p25 in complex with an ATP analogue | x-ray diffraction | D, E | — | — |
| 3O0G | Crystal structure of CDK5:P25 in complex with an ATP analogue | x-ray diffraction | D, E | — | — |
| 6LDP | Structure of CDK5R1-bound FEM1C | x-ray diffraction | A, B | SO4 | — |
| 6LDP | Structure of CDK5R1-bound FEM1C | x-ray diffraction | A, B | SO4 | — |
| 7VDP | The structure of cyclin-dependent kinase 5 (CDK5) in complex with P25 and compound 1 | x-ray diffraction | C, D | CL | — |
| 7VDQ | The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 7 | x-ray diffraction | C, D | — | 6 (best 0.77) |
| 7VDQ | The structure of cyclin-dependent kinase 5 (CDK5) in complex with P25 and compound 7 | x-ray diffraction | C, D | — | — |
| 7VDR | The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 13 | x-ray diffraction | C, D | — | 3 (best 0.72) |
| 7VDR | The structure of cyclin-dependent kinase 5 (CDK5) in complex with P25 and compound 13 | x-ray diffraction | C, D | — | — |
| 7VDS | The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 24 | x-ray diffraction | C, D | CL | — |
| 7VDS | The structure of cyclin-dependent kinase 5 (CDK5) in complex with P25 and compound 24 | x-ray diffraction | C, D | CL | — |
| Q15078 | AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 5 activator 1 (Q15078) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7VDP chain C against the predicted model Q15078: TM-score 1.00, RMSD 0.21 Å
- 7VDR chain C against the predicted model Q15078: TM-score 1.00, RMSD 0.23 Å
- 7VDR chain C against the predicted model Q15078: TM-score 1.00, RMSD 0.23 Å
- 7VDQ chain C against the predicted model Q15078: TM-score 1.00, RMSD 0.28 Å
- 7VDQ chain C against the predicted model Q15078: TM-score 1.00, RMSD 0.28 Å
- 7VDS chain C against the predicted model Q15078: TM-score 1.00, RMSD 0.30 Å
- 7VDS chain C against the predicted model Q15078: TM-score 1.00, RMSD 0.30 Å
- 1UNL chain D against the predicted model Q15078: TM-score 0.99, RMSD 0.47 Å
- 1UNL chain D against the predicted model Q15078: TM-score 0.99, RMSD 0.47 Å
- 3O0G chain D against the predicted model Q15078: TM-score 0.99, RMSD 0.47 Å
Elsewhere
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