UniProt Q15007
Pre-mRNA-splicing regulator WTAP (Q15007)
Pre-mRNA-splicing regulator WTAP (UniProt Q15007): 4 experimental structures and 1 predicted model on GenesisL1, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15007
- Protein
- Pre-mRNA-splicing regulator WTAP
- Experimental structures
- 4
- Predicted models
- 1
- Pockets
- 23 · 3 records with a druggable one
Structures
5 records of Q15007 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7VF2 | Human m6A-METTL associated complex (WTAP, VIRMA, ZC3H13, and HAKAI) | electron microscopy | C, D | — | 9 (best 0.64) |
| 7VF5 | Human m6A-METTL associated complex (WTAP, VIRMA, and HAKAI) | electron microscopy | C, D | — | 10 (best 0.76) |
| 7YFJ | Crystal structure of human WTAP | x-ray diffraction | A, B | — | — |
| 7YG4 | Structure of WTAP-VIRMA in the m6A writer complex | electron microscopy | B, E | — | 4 (best 0.59) |
| Q15007 | AlphaFold monomer V2.0 prediction for pre-mRNA-splicing regulator wtap (Q15007) | predicted | A | — | — |
Experiment against prediction
- 7YG4 chain E against the predicted model Q15007: TM-score 0.88, RMSD 1.10 Å
- 7YG4 chain B against the predicted model Q15007: TM-score 0.81, RMSD 2.08 Å
- 7YFJ chain B against the predicted model Q15007: TM-score 0.70, RMSD 2.78 Å
- 7YFJ chain A against the predicted model Q15007: TM-score 0.63, RMSD 3.28 Å
- 7VF5 chain D against the predicted model Q15007: TM-score 0.48, RMSD 2.10 Å
- 7VF2 chain D against the predicted model Q15007: TM-score 0.46, RMSD 2.49 Å
- 7VF2 chain C against the predicted model Q15007: TM-score 0.40, RMSD 3.50 Å
- 7VF5 chain C against the predicted model Q15007: TM-score 0.40, RMSD 3.03 Å
Elsewhere
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