UniProt Q14318
Peptidyl-prolyl cis-trans isomerase FKBP8 (Q14318)
Peptidyl-prolyl cis-trans isomerase FKBP8 (UniProt Q14318), EC 5.2.1.8: 10 experimental structures and 1 predicted model on GenesisL1, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q14318
- Protein
- Peptidyl-prolyl cis-trans isomerase FKBP8
- EC
- 5.2.1.8
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 13 · 1 record with a druggable one
Structures
11 records of Q14318 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AWG | Structure of the PPIase domain of the Human FK506-binding protein 8 | x-ray diffraction | A | — | — |
| 2AWG | Structure of the ppiase domain of the human FK506-binding protein 8 | x-ray diffraction | A | — | — |
| 2F2D | Solution structure of the FK506-binding domain of human FKBP38 | solution nmr | A | — | — |
| 2F2D | Solution structure of the FK506-binding domain of human FKBP38 | solution nmr | A | — | — |
| 2MF9 | Solution structure of the N-terminal domain of human FKBP38 (FKBP38NTD) | solution nmr | A | — | — |
| 2MF9 | Solution structure of the N-terminal domain of human FKBP38 (FKBP38NTD) | solution nmr | A | — | — |
| 3EY6 | Crystal structure of the FK506-binding domain of human FKBP38 | x-ray diffraction | A | — | — |
| 3EY6 | Crystal structure of the FK506-binding domain of human FKBP38 | x-ray diffraction | A | — | — |
| 5MGX | The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90 | x-ray diffraction | E, F, G, H | — | 13 (best 0.54) |
| 5MGX | The structure of FKBP38 in complex with the meevd tetratricopeptide binding-motif of HSP90 | x-ray diffraction | E, F, G, H | — | — |
| Q14318 | AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP8 (Q14318) | predicted | A | — | — |
Experiment against prediction
- 5MGX chain H against the predicted model Q14318: TM-score 0.99, RMSD 0.63 Å
- 5MGX chain H against the predicted model Q14318: TM-score 0.99, RMSD 0.63 Å
- 5MGX chain E against the predicted model Q14318: TM-score 0.99, RMSD 0.64 Å
- 5MGX chain E against the predicted model Q14318: TM-score 0.99, RMSD 0.64 Å
- 5MGX chain F against the predicted model Q14318: TM-score 0.99, RMSD 0.70 Å
- 5MGX chain F against the predicted model Q14318: TM-score 0.99, RMSD 0.70 Å
- 5MGX chain G against the predicted model Q14318: TM-score 0.99, RMSD 0.71 Å
- 5MGX chain G against the predicted model Q14318: TM-score 0.99, RMSD 0.71 Å
- 3EY6 chain A against the predicted model Q14318: TM-score 0.94, RMSD 1.13 Å
- 3EY6 chain A against the predicted model Q14318: TM-score 0.94, RMSD 1.13 Å
Elsewhere
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