UniProt Q14181
DNA polymerase alpha subunit B (Q14181)
DNA polymerase alpha subunit B (UniProt Q14181): 18 experimental structures and 1 predicted model on GenesisL1, 41 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q14181
- Protein
- DNA polymerase alpha subunit B
- Experimental structures
- 18
- Predicted models
- 1
- Pockets
- 41 · 6 records with a druggable one
Structures
19 records of Q14181 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KEB | NMR solution structure of the N-terminal domain of the DNA polymerase alpha p68 subunit | solution nmr | A | — | — |
| 2KEB | NMR solution structure of the N-terminal domain of the DNA polymerase alpha P68 subunit | solution nmr | A | — | — |
| 4E2I | The Complex Structure of the SV40 Helicase Large T Antigen and p68 Subunit of DNA Polymerase… | x-ray diffraction | 2, 3, 6, U, W, 5, 7, 9, 1, 4, 8 | — | — |
| 4E2I | The complex structure of the SV40 helicase large T antigen and P68 subunit of DNA polymerase… | x-ray diffraction | 2, 3, 6, U, W, 5, 7, 9, 1, 4, 8 | — | — |
| 4Y97 | Crystal Structure of human Pol alpha B-subunit in complex with C-terminal domain of catalytic… | x-ray diffraction | A, C, E, G | — | — |
| 4Y97 | Crystal structure of human pol alpha B-subunit in complex with C- terminal domain of catalytic… | x-ray diffraction | A, C, E, G | — | — |
| 5EXR | Crystal structure of human primosome | x-ray diffraction | D, H | — | — |
| 5EXR | Crystal structure of human primosome | x-ray diffraction | D, H | — | — |
| 7OPL | Cryoem structure of DNA polymerase alpha - primase bound to SARS cov NSP1 | electron microscopy | B | — | — |
| 7U5C | Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | D | — | 3 (best 0.80) |
| 7U5C | Cryo-EM structure of human cst bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | D | — | — |
| 8D0B | Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template | electron microscopy | G | — | 7 (best 0.73) |
| 8D0B | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template | electron microscopy | G | — | — |
| 8D0K | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template… | electron microscopy | G | — | — |
| 8D9D | Human DNA polymerase-alpha/primase elongation complex II bound to primer/template | electron microscopy | D | — | 6 (best 0.76) |
| 8QJ7 | Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1 | electron microscopy | B | — | 8 (best 0.77) |
| 8VY3 | Human DNA polymerase alpha/primase - AavLEA1 (1:40 molar ratio) | electron microscopy | D | — | 8 (best 0.75) |
| 9C8V | Human DNA polymerase alpha/primase - CHAPSO (4 mM) | electron microscopy | D | — | 9 (best 0.87) |
| Q14181 | AlphaFold monomer V2.0 prediction for DNA polymerase alpha subunit B (Q14181) | predicted | A | — | — |
Experiment against prediction
- 4Y97 chain G against the predicted model Q14181: TM-score 0.99, RMSD 0.91 Å
- 4Y97 chain G against the predicted model Q14181: TM-score 0.99, RMSD 0.91 Å
- 8D0B chain G against the predicted model Q14181: TM-score 0.98, RMSD 1.06 Å
- 8D0B chain G against the predicted model Q14181: TM-score 0.98, RMSD 1.06 Å
- 4Y97 chain C against the predicted model Q14181: TM-score 0.98, RMSD 1.10 Å
- 4Y97 chain C against the predicted model Q14181: TM-score 0.98, RMSD 1.10 Å
- 5EXR chain D against the predicted model Q14181: TM-score 0.98, RMSD 1.23 Å
- 5EXR chain D against the predicted model Q14181: TM-score 0.98, RMSD 1.23 Å
- 5EXR chain H against the predicted model Q14181: TM-score 0.98, RMSD 1.23 Å
- 5EXR chain H against the predicted model Q14181: TM-score 0.98, RMSD 1.23 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.