UniProt Q13619
Cullin-4A (Q13619)
Cullin-4A (UniProt Q13619): 10 experimental structures and 1 predicted model on GenesisL1, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13619
- Protein
- Cullin-4A
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 18 · 3 records with a druggable one
Structures
11 records of Q13619 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2HYE | Crystal Structure of the DDB1-Cul4A-Rbx1-SV5V Complex | x-ray diffraction | C | — | — |
| 2HYE | Crystal structure of the DDB1-CUL4A-RBX1-SV5V complex | x-ray diffraction | C | — | — |
| 4A0K | Structure of DDB1-DDB2-CUL4A-RBX1 bound to a 12 bp abasic site containing DNA-duplex | x-ray diffraction | A | — | — |
| 4A0K | Structure of DDB1-DDB2-CUL4A-RBX1 bound to a 12 bp abasic site containing DNA-duplex | x-ray diffraction | A | — | — |
| 7OKQ | Cryo-EM structure of the DDB1-DCAF1-CUL4A-RBX1 complex | electron microscopy | C, G, K, O | — | — |
| 7OPC | Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 4) | electron microscopy | e | — | 1 (best 0.73) |
| 7OPC | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 4) | electron microscopy | e | — | — |
| 7OPD | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 5) | electron microscopy | e | — | — |
| 8B3G | C(N)RL4CSA-UVSSA-E2-ubiquitin complex. | electron microscopy | e | — | 8 (best 0.81) |
| 8B3I | CRL4CSA-E2-Ub (state 2) | electron microscopy | e | — | 9 (best 0.81) |
| Q13619 | AlphaFold monomer V2.0 prediction for cullin-4A (Q13619) | predicted | A | — | — |
Experiment against prediction
- 4A0K chain A against the predicted model Q13619: TM-score 0.98, RMSD 1.43 Å
- 4A0K chain A against the predicted model Q13619: TM-score 0.98, RMSD 1.43 Å
- 2HYE chain C against the predicted model Q13619: TM-score 0.96, RMSD 1.95 Å
- 2HYE chain C against the predicted model Q13619: TM-score 0.96, RMSD 1.95 Å
- 7OPD chain e against the predicted model Q13619: TM-score 0.95, RMSD 2.23 Å
- 7OPC chain e against the predicted model Q13619: TM-score 0.95, RMSD 2.23 Å
- 7OPC chain e against the predicted model Q13619: TM-score 0.95, RMSD 2.23 Å
- 8B3G chain e against the predicted model Q13619: TM-score 0.91, RMSD 2.14 Å
- 8B3I chain e against the predicted model Q13619: TM-score 0.91, RMSD 2.14 Å
- 7OKQ chain C against the predicted model Q13619: TM-score 0.89, RMSD 3.28 Å
Elsewhere
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