UniProt Q13617
Cullin-2 (Q13617)
Cullin-2 (UniProt Q13617): 20 experimental structures and 1 predicted model on GenesisL1, 136 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13617
- Protein
- Cullin-2
- Experimental structures
- 20
- Predicted models
- 1
- Pockets
- 136 · 12 records with a druggable one
Structures
21 records of Q13617 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4WQO | Structure of vhl-elob-eloc-CUL2 | x-ray diffraction | D | — | — |
| 5N4W | Crystal structure of the Cul2-Rbx1-EloBC-VHL ubiquitin ligase complex | x-ray diffraction | A | — | 11 (best 0.77) |
| 5N4W | Crystal structure of the CUL2-RBX1-elobc-vhl ubiquitin ligase complex | x-ray diffraction | A | — | — |
| 6R6H | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | electron microscopy | O | — | 8 (best 0.82) |
| 6R6H | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | O | — | — |
| 6R7F | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | O | — | — |
| 6R7H | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | O | — | — |
| 6R7I | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | O | — | — |
| 6R7N | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | O | — | — |
| 7PLO | H. sapiens replisome-CUL2/LRR1 complex | electron microscopy | S | — | — |
| 8IJ1 | Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | electron microscopy | A, F | — | 14 (best 0.78) |
| 8JAL | Structure of CRL2APPBP2 bound with RxxGP degron (dimer) | electron microscopy | E, I | — | 9 (best 0.71) |
| 8JAS | Structure of CRL2APPBP2 bound with RxxGPAA degron (tetramer) | electron microscopy | E, I, L, U | — | 12 (best 0.86) |
| 8JAV | Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (tetramer) | electron microscopy | E, I, L, U | — | 10 (best 0.87) |
| 8R5H | Ubiquitin ligation to neosubstrate by a cullin-RING E3 ligase & Cdc34… | electron microscopy | A | — | 12 (best 0.82) |
| 8RWZ | Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL | electron microscopy | E | — | 6 (best 0.63) |
| 8RX0 | (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub | electron microscopy | E | — | 7 (best 0.67) |
| 8WQE | Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 1) | electron microscopy | C, A | — | 15 (best 0.76) |
| 8WQF | cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 2) | electron microscopy | A, B | — | 18 (best 0.80) |
| 8WQH | cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89… | electron microscopy | C, A | — | 14 (best 0.76) |
| Q13617 | AlphaFold monomer V2.0 prediction for cullin-2 (Q13617) | predicted | A | — | — |
Experiment against prediction
- 8JAL chain E against the predicted model Q13617: TM-score 0.98, RMSD 0.79 Å
- 8JAL chain I against the predicted model Q13617: TM-score 0.98, RMSD 0.89 Å
- 8JAS chain E against the predicted model Q13617: TM-score 0.97, RMSD 0.93 Å
- 8JAV chain U against the predicted model Q13617: TM-score 0.97, RMSD 1.68 Å
- 8JAS chain U against the predicted model Q13617: TM-score 0.97, RMSD 1.67 Å
- 8JAV chain E against the predicted model Q13617: TM-score 0.97, RMSD 1.01 Å
- 8JAV chain I against the predicted model Q13617: TM-score 0.96, RMSD 1.84 Å
- 8JAS chain I against the predicted model Q13617: TM-score 0.96, RMSD 1.85 Å
- 8JAV chain L against the predicted model Q13617: TM-score 0.96, RMSD 0.97 Å
- 8WQF chain A against the predicted model Q13617: TM-score 0.95, RMSD 2.11 Å
Elsewhere
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