UniProt Q13616
Cullin-1 (Q13616)
Cullin-1 (UniProt Q13616): 39 experimental structures and 1 predicted model on GenesisL1, 141 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13616
- Protein
- Cullin-1
- Experimental structures
- 39
- Predicted models
- 1
- Pockets
- 141 · 14 records with a druggable one
Structures
40 records of Q13616 in the MolNFT archive: 39 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LDJ | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | x-ray diffraction | A | — | — |
| 1LDJ | Structure of the CUL1-RBX1-SKP1-F BOXSKP2 scf ubiquitin ligase complex | x-ray diffraction | A | — | — |
| 1LDK | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | x-ray diffraction | A, B | — | — |
| 1LDK | Structure of the CUL1-RBX1-SKP1-F BOXSKP2 scf ubiquitin ligase complex | x-ray diffraction | A, B | — | — |
| 1U6G | Crystal Structure of The Cand1-Cul1-Roc1 Complex | x-ray diffraction | A | — | — |
| 1U6G | Crystal structure of the CAND1-CUL1-ROC1 complex | x-ray diffraction | A | — | — |
| 3RTR | A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into… | x-ray diffraction | A, C, E, G | — | — |
| 3RTR | A ring E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into… | x-ray diffraction | A, C, E, G | — | — |
| 3TDU | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex… | x-ray diffraction | C, D | — | — |
| 3TDU | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex… | x-ray diffraction | C, D | — | — |
| 3TDZ | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex… | x-ray diffraction | C, D | — | — |
| 3TDZ | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex… | x-ray diffraction | C, D | — | — |
| 4F52 | Structure of a Glomulin-RBX1-CUL1 complex | x-ray diffraction | A, C | — | — |
| 4F52 | Structure of a glomulin-RBX1-CUL1 complex | x-ray diffraction | A, C | — | — |
| 4P5O | Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a RING-E3-E2~ubiquitin-like protein-substrate… | x-ray diffraction | A, C | — | — |
| 4P5O | Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a ring-E3- E2~UBIQUITIN-like protein-substrate… | x-ray diffraction | A, C | — | — |
| 5V89 | Structure of DCN4 PONY domain bound to CUL1 WHB | x-ray diffraction | C | — | 2 (best 0.51) |
| 5V89 | Structure of DCN4 pony domain bound to CUL1 whb | x-ray diffraction | C | — | — |
| 6TTU | Ubiquitin ligation to substrate by a cullin-ring E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1… | electron microscopy | C | — | — |
| 6WCQ | Structure of a substrate-bound DQC ubiquitin ligase | electron microscopy | D | — | 3 (best 0.70) |
| 6WCQ | Structure of a substrate-bound dqc ubiquitin ligase | electron microscopy | D | — | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly… | electron microscopy | C | — | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | C | — | — |
| 7B5M | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly… | electron microscopy | C | — | 9 (best 0.65) |
| 7B5M | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | C | — | — |
| 7B5N | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | C | — | — |
| 7B5R | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | C | — | — |
| 7B5S | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly: CUL1-RBX1-ARIH1… | electron microscopy | C | — | — |
| 7Z8T | CAND1-SCF-SKP2 CAND1 engaged SCF rocked | electron microscopy | C | — | 16 (best 0.85) |
| 7Z8V | CAND1-SCF-SKP2 (SKP1deldel) CAND1 engaged SCF rocked | electron microscopy | C | — | 15 (best 0.85) |
| 7ZBW | CAND1-SCF-SKP2 CAND1 rolling-2 SCF engaged | electron microscopy | C | — | 13 (best 0.75) |
| 7ZBZ | CAND1 delhairpin-SCF-SKP2 CAND1 partly engaged SCF partly rocked | electron microscopy | C | — | 14 (best 0.86) |
| 8CDJ | CAND1 b-hairpin++-SCF-SKP2 CAND1 rolling SCF engaged | electron microscopy | C | — | 13 (best 0.78) |
| 8CDK | CAND1 b-hairpin++-SCF-SKP2 CAND1 partly engaged SCF partly rocked | electron microscopy | C | — | 14 (best 0.84) |
| 8OR0 | CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 | electron microscopy | A | — | 8 (best 0.86) |
| 8OR3 | CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 | electron microscopy | A | — | 13 (best 0.85) |
| 8UA6 | Cryo-EM Structure of SCF-FBOX22-BACH1BTB | electron microscopy | A | — | 7 (best 0.59) |
| 8UBU | Cryo-EM structure of dimeric SCF-FBXL17-BACH1BTB E3 ligase complex close conformation | electron microscopy | A, H | — | 4 (best 0.74) |
| 9JKB | Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO4 SCF ubiquition ligase complex | electron microscopy | A | — | 10 (best 0.73) |
| Q13616 | AlphaFold monomer V2.0 prediction for cullin-1 (Q13616) | predicted | A | — | — |
Experiment against prediction
- 3TDU chain C against the predicted model Q13616: TM-score 0.98, RMSD 0.43 Å
- 3TDU chain C against the predicted model Q13616: TM-score 0.98, RMSD 0.43 Å
- 6WCQ chain D against the predicted model Q13616: TM-score 0.98, RMSD 1.06 Å
- 6WCQ chain D against the predicted model Q13616: TM-score 0.98, RMSD 1.06 Å
- 1LDK chain A against the predicted model Q13616: TM-score 0.97, RMSD 1.10 Å
- 1LDK chain A against the predicted model Q13616: TM-score 0.97, RMSD 1.10 Å
- 5V89 chain C against the predicted model Q13616: TM-score 0.97, RMSD 0.50 Å
- 5V89 chain C against the predicted model Q13616: TM-score 0.97, RMSD 0.50 Å
- 9JKB chain A against the predicted model Q13616: TM-score 0.97, RMSD 1.60 Å
- 3TDU chain D against the predicted model Q13616: TM-score 0.97, RMSD 0.67 Å
Elsewhere
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