UniProt Q13547
Histone deacetylase 1 (Q13547)
Histone deacetylase 1 (UniProt Q13547), EC 3.5.1.-, 3.5.1.98: 14 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 50 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q13547
- Protein
- Histone deacetylase 1
- EC
- 3.5.1.-, 3.5.1.98
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 50 · 4 records with a druggable one
Structures
15 records of Q13547 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4BKX | The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex | x-ray diffraction | B | — | — |
| 4BKX | The structure of HDAC1 in complex with the dimeric ELM2-sant domain of MTA1 from the nurd complex | x-ray diffraction | B | — | — |
| 5ICN | HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4 | x-ray diffraction | B | IHP, ZN, K | — |
| 5ICN | HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4 | x-ray diffraction | B | — | — |
| 6Z2J | The structure of the dimeric HDAC1/MIDEAS/DNTTIP1 midac deacetylase complex | electron microscopy | C, E | IHP, ZN, K | — |
| 6Z2K | The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 midac deacetylase complex | electron microscopy | C, E, K, I | ZN, K, IHP | — |
| 7AO8 | Structure of the MTA1/HDAC1/MBD2 NURD deacetylase complex | electron microscopy | E, B | IHP, ZN, K | 16 (best 0.71) |
| 7AO8 | Structure of the MTA1/HDAC1/MBD2 nurd deacetylase complex | electron microscopy | E, B | IHP, ZN, K | — |
| 7AO9 | Structure of the core MTA1/HDAC1/MBD2 NURD deacetylase complex | electron microscopy | E, B | IHP, ZN, K | 13 (best 0.73) |
| 7AO9 | Structure of the core MTA1/HDAC1/MBD2 nurd deacetylase complex | electron microscopy | E, B | IHP, ZN, K | — |
| 7AOA | Structure of the extended MTA1/HDAC1/MBD2/RBBP4 NURD deacetylase complex | electron microscopy | E, B | IHP, ZN, K | 13 (best 0.72) |
| 7AOA | Structure of the extended MTA1/HDAC1/MBD2/RBBP4 nurd deacetylase complex | electron microscopy | E, B | IHP, ZN, K | — |
| 7SME | P107 pocket domain complexed with HDAC1 peptide | x-ray diffraction | B | — | — |
| 8VOJ | The Cryo-EM structure of LSD1-CoREST-HDAC1 in complex with KBTBD4 enhanced by UM171 and IP6 | electron microscopy | C | ZN, IHP, A1ACV | 8 (best 0.62) |
| Q13547 | AlphaFold monomer V2.0 prediction for histone deacetylase 1 (Q13547) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7AO9 chain B against the predicted model Q13547: TM-score 0.99, RMSD 0.64 Å
- 7AO9 chain B against the predicted model Q13547: TM-score 0.99, RMSD 0.64 Å
- 7AO8 chain B against the predicted model Q13547: TM-score 0.99, RMSD 0.64 Å
- 7AOA chain B against the predicted model Q13547: TM-score 0.99, RMSD 0.64 Å
- 7AO8 chain B against the predicted model Q13547: TM-score 0.99, RMSD 0.64 Å
- 7AOA chain B against the predicted model Q13547: TM-score 0.99, RMSD 0.64 Å
- 5ICN chain B against the predicted model Q13547: TM-score 0.99, RMSD 0.64 Å
- 5ICN chain B against the predicted model Q13547: TM-score 0.99, RMSD 0.64 Å
- 7AO8 chain E against the predicted model Q13547: TM-score 0.99, RMSD 0.64 Å
- 7AO8 chain E against the predicted model Q13547: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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