UniProt Q13526
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Q13526)
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (UniProt Q13526), EC 5.2.1.8: 219 experimental structures on GenesisL1, 38 ligands bound, 27 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q13526
- Protein
- Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
- EC
- 5.2.1.8
- Experimental structures
- 219
- Predicted models
- 0
- Ligands
- 38
- Pockets
- 27 · 7 records with a druggable one
Structures
219 records of Q13526 in the MolNFT archive: 219 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F8A | Structural basis for the phosphoserine-proline recognition by group IV ww domains | x-ray diffraction | B | — | — |
| 1F8A | Structural basis for the phosphoserine-proline recognition by group IV ww domains | x-ray diffraction | B | — | — |
| 1I6C | Solution structure of PIN1 ww domain | solution nmr | A | — | — |
| 1I6C | Solution structure of PIN1 ww domain | solution nmr | A | — | — |
| 1I8G | Solution structure of PIN1 ww domain complexed with CDC25 phosphothreonine peptide | solution nmr | B | — | — |
| 1I8G | Solution structure of PIN1 ww domain complexed with CDC25 phosphothreonine peptide | solution nmr | B | — | — |
| 1I8H | Solution structure of PIN1 ww domain complexed with human tau phosphothreonine peptide | solution nmr | B | — | — |
| 1I8H | Solution structure of PIN1 ww domain complexed with human tau phosphothreonine peptide | solution nmr | B | — | — |
| 1NMV | Solution structure of human Pin1 | solution nmr | A | — | — |
| 1NMV | Solution structure of human PIN1 | solution nmr | A | — | — |
| 1NMW | Solution structure of the PPIase domain of human Pin1 | solution nmr | A | — | — |
| 1NMW | Solution structure of the ppiase domain of human PIN1 | solution nmr | A | — | — |
| 1PIN | PIN1 peptidyl-prolyl cis-trans isomerase from homo sapiens | x-ray diffraction | A | — | — |
| 1PIN | PIN1 peptidyl-prolyl cis-trans isomerase from homo sapiens | x-ray diffraction | A | — | — |
| 1ZCN | human Pin1 Ng mutant | x-ray diffraction | A | — | — |
| 1ZCN | Human PIN1 ng mutant | x-ray diffraction | A | — | — |
| 2F21 | human Pin1 Fip mutant | x-ray diffraction | A | — | — |
| 2F21 | Human PIN1 fip mutant | x-ray diffraction | A | — | — |
| 2ITK | human Pin1 bound to D-PEPTIDE | x-ray diffraction | A | — | — |
| 2ITK | Human PIN1 bound to D-peptide | x-ray diffraction | A | — | — |
| 2KBU | NMR solution structure of Pin1 WW domain mutant with beta turn mimic at position 12 | solution nmr | A | — | — |
| 2KBU | NMR solution structure of PIN1 ww domain mutant with beta turn mimic at position 12 | solution nmr | A | — | — |
| 2KCF | The NMR solution structure of the isolated Apo Pin1 WW domain | solution nmr | A | — | — |
| 2KCF | The NMR solution structure of the isolated apo PIN1 ww domain | solution nmr | A | — | — |
| 2LB3 | Structure of the WW domain of PIN1 in complex with a human phosphorylated Smad3 derived peptide | solution nmr | A | — | — |
| 2LB3 | Structure of the ww domain of PIN1 in complex with a human phosphorylated SMAD3 derived peptide | solution nmr | A | — | — |
| 2M8I | Structure of Pin1 WW domain | solution nmr | A | — | — |
| 2M8I | Structure of PIN1 ww domain | solution nmr | A | — | — |
| 2M8J | Structure of Pin1 WW domain phospho-mimic S16E | solution nmr | A | — | — |
| 2M8J | Structure of PIN1 ww domain phospho-mimic S16E | solution nmr | A | — | — |
| 2M9E | NMR solution structure of Pin1 WW domain mutant 5-1 | solution nmr | A | — | — |
| 2M9E | NMR solution structure of PIN1 ww domain mutant 5-1 | solution nmr | A | — | — |
| 2M9F | NMR solution structure of Pin1 WW domain mutant 5-1g | solution nmr | A | — | — |
| 2M9F | NMR solution structure of PIN1 ww domain mutant 5-1G | solution nmr | A | — | — |
| 2M9I | NMR solution structure of Pin1 WW domain variant 6-1 | solution nmr | A | — | — |
| 2M9I | NMR solution structure of PIN1 ww domain variant 6-1 | solution nmr | A | — | — |
| 2M9J | NMR solution structure of Pin1 WW domain mutant 6-1g | solution nmr | A | — | — |
| 2M9J | NMR solution structure of PIN1 ww domain mutant 6-1G | solution nmr | A | — | — |
| 2N1O | PIN1 WW domain in complex with a phosphorylated CPEB1 derived peptide | solution nmr | A | — | — |
| 2N1O | PIN1 ww domain in complex with a phosphorylated CPEB1 derived peptide | solution nmr | A | — | — |
| 2Q5A | human Pin1 bound to L-PEPTIDE | x-ray diffraction | A | — | — |
| 2Q5A | Human PIN1 bound to L-peptide | x-ray diffraction | A | — | — |
| 2RUC | Solution structure of the peptidyl prolyl cis-trans isomerase domain of human Pin1 with sulfate ion | solution nmr | A | — | — |
| 2RUC | Solution structure of the peptidyl prolyl cis-trans isomerase domain of human PIN1 with sulfate ion | solution nmr | A | — | — |
| 2RUD | Solution structure of the peptidyl prolyl cis-trans isomerase domain of C113D mutant human Pin1… | solution nmr | A | — | — |
| 2RUD | Solution structure of the peptidyl prolyl cis-trans isomerase domain of C113D mutant human PIN1… | solution nmr | A | — | — |
| 2RUQ | solution structure of human Pin1 PPIase mutant C113A | solution nmr | A | — | — |
| 2RUQ | Solution structure of human PIN1 ppiase mutant C113A | solution nmr | A | — | — |
| 2RUR | Solution structure of Human Pin1 PPIase C113S mutant | solution nmr | A | — | — |
| 2RUR | Solution structure of human PIN1 ppiase C113S mutant | solution nmr | A | — | — |
| 2XP3 | Discovery of cell-active phenyl-imidazole PIN1 inhibitors by structure-guided fragment evolution | x-ray diffraction | A | — | — |
| 2XP3 | Discovery of cell-active phenyl-imidazole PIN1 inhibitors by structure-guided fragment evolution | x-ray diffraction | A | — | — |
| 2XP4 | Discovery of cell-active phenyl-imidazole PIN1 inhibitors by structure-guided fragment evolution | x-ray diffraction | A | — | — |
| 2XP4 | Discovery of cell-active phenyl-imidazole PIN1 inhibitors by structure-guided fragment evolution | x-ray diffraction | A | — | — |
| 2XP5 | Discovery of cell-active phenyl-imidazole PIN1 inhibitors by structure-guided fragment evolution | x-ray diffraction | A | — | — |
| 2XP5 | Discovery of cell-active phenyl-imidazole PIN1 inhibitors by structure-guided fragment evolution | x-ray diffraction | A | — | — |
| 2XP6 | Discovery of cell-active phenyl-imidazole PIN1 inhibitors by structure-guided fragment evolution | x-ray diffraction | A | — | — |
| 2XP6 | Discovery of cell-active phenyl-imidazole PIN1 inhibitors by structure-guided fragment evolution | x-ray diffraction | A | — | — |
| 2XP7 | Discovery of cell-active phenyl-imidazole PIN1 inhibitors by structure-guided fragment evolution | x-ray diffraction | A | — | — |
| 2XP7 | Discovery of cell-active phenyl-imidazole PIN1 inhibitors by structure-guided fragment evolution | x-ray diffraction | A | — | — |
159 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 13 records
- 0AW · ~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-5-carboxamide · in 2 records
- ACE · Acetyl group · in 2 records
- CL · Chloride ion · in 2 records
- J2C · 8-(2-chloroacetyl)-4-(furan-2-ylmethyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one · in 2 records
- S6B · 3-chloranyl-4-imidazol-1-yl-benzaldehyde · in 2 records
- SGH · 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole · in 2 records
- TAS · Trihydroxyarsenite(iii) · in 2 records
- TJ8 · 2-bromanyl-4-(2-phenylimidazol-1-yl)benzaldehyde · in 2 records
- TKH · [4-[2-[2,4-bis(fluoranyl)phenyl]imidazol-1-yl]-2-bromanyl-phenyl]methanol · in 2 records
- TKK · 1-(3-bromanyl-4-methyl-phenyl)-2-(2-bromophenyl) imidazole · in 2 records
- TLQ · 4-(2-phenylimidazol-1-yl)naphthalene-1-carbaldehyde · in 2 records
- TQK · 2-methyl-4-(2-phenylimidazol-1-yl)benzaldehyde · in 2 records
- UG5 · 4-[4-(trifluoromethyl)imidazol-1-yl]benzaldehyde · in 2 records
- UPQ · 4-(4-methylimidazol-1-yl)benzaldehyde · in 2 records
- 09W · ~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-7-carboxamide · in 1 record
- 0BF · 8-(2-chloranylethanoyl)-4-[(5-naphthalen-1-ylfuran-2-yl)methyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one · in 1 record
- A1ACH · Nalpha-{(2S)-1-[(3S)-2-acetyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonyl]piperidine-2-carbonyl}-5-fluoro-L-tryptophanamide · in 1 record
- A1D9K · ~{N}-[(2~{S})-3-[1-[4-(4-cyanophenyl)phenyl]-1,2,3-triazol-4-yl]-1-[(3-oxidanylcyclobutyl)amino]-1-oxidanylidene-propan-2-yl]-1-phenyl-cyclopropane-1-carboxamide · in 1 record
- CIR · Citrulline · in 1 record
- FSC · Fusicoccin · in 1 record
- J3X · 4-((5-bromofuran-2-yl)methyl)-8-(2-chloroacetyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one · in 1 record
- J50 · 8-(2-chloroacetyl)-4-((5-phenylfuran-2-yl)methyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one · in 1 record
- JFS · [4-(1H-benzimidazol-1-yl)phenyl]methanol · in 1 record
- NIT · 4-nitroaniline · in 1 record
- P3G · 3,6,9,12,15-pentaoxaheptadecane · in 1 record
- P5N · 1-(4-methylphenyl)imidazole · in 1 record
- QT7 · 2-chloro-N-(2,2-dimethylpropyl)-N-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]acetamide · in 1 record
- S9E · 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde · in 1 record
- SFW · 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.