UniProt Q13503
Mediator of RNA polymerase II transcription subunit 21 (Q13503)
Mediator of RNA polymerase II transcription subunit 21 (UniProt Q13503): 9 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13503
- Protein
- Mediator of RNA polymerase II transcription subunit 21
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 3 · 2 records with a druggable one
Structures
10 records of Q13503 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | U | — | 1 (best 0.74) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | U | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | u | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | u | — | — |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | U | — | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | n | — | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | n | — | — |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | u | — | — |
| 8TQW | Structure of human transcriptional Mediator complex | electron microscopy | U | — | 2 (best 0.82) |
| Q13503 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 21… | predicted | A | — | — |
Experiment against prediction
- 8GXQ chain u against the predicted model Q13503: TM-score 0.86, RMSD 1.81 Å
- 7NVR chain n against the predicted model Q13503: TM-score 0.81, RMSD 2.38 Å
- 7NVR chain n against the predicted model Q13503: TM-score 0.81, RMSD 2.38 Å
- 7ENJ chain U against the predicted model Q13503: TM-score 0.81, RMSD 2.10 Å
- 7EMF chain U against the predicted model Q13503: TM-score 0.81, RMSD 2.10 Å
- 7EMF chain U against the predicted model Q13503: TM-score 0.81, RMSD 2.10 Å
- 7ENA chain u against the predicted model Q13503: TM-score 0.76, RMSD 2.21 Å
- 7ENC chain u against the predicted model Q13503: TM-score 0.75, RMSD 2.33 Å
- 8TQW chain U against the predicted model Q13503: TM-score 0.73, RMSD 2.81 Å
Elsewhere
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