UniProt Q13490
Baculoviral IAP repeat-containing protein 2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (UniProt Q13490), EC 2.3.2.27, 6.3.2.-: 51 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 15 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q13490
- Protein
- Baculoviral IAP repeat-containing protein 2
- EC
- 2.3.2.27, 6.3.2.-
- Experimental structures
- 51
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 15 · 3 records with a druggable one
Structures
52 records of Q13490 in the MolNFT archive: 51 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1QBH | Solution structure of a baculoviral inhibitor of apoptosis (iap) repeat | solution nmr | A | — | — |
| 1QBH | Solution structure of a baculoviral inhibitor of apoptosis (iap) repeat | solution nmr | A | — | — |
| 2L9M | Structure of cIAP1 CARD | solution nmr | A | — | — |
| 2L9M | Structure of CIAP1 card | solution nmr | A | — | — |
| 3D9T | CIAP1-BIR3 in complex with N-terminal peptide from Caspase-9 (ATPFQE) | x-ray diffraction | A, B | — | — |
| 3D9T | CIAP1-BIR3 in complex with N-terminal peptide from caspase- 9 (atpfqe) | x-ray diffraction | A, B | — | — |
| 3D9U | The BIR3 domain of cIAP1 in complex with the N terminal peptide from SMAC/DIABLO (AVPIAQ). | x-ray diffraction | A | — | — |
| 3D9U | The BIR3 domain of CIAP1 in complex with the N terminal peptide from SMAC/DIABLO (avpiaq). | x-ray diffraction | A | — | — |
| 3M1D | Structure of BIR1 from cIAP1 | x-ray diffraction | A, B | — | — |
| 3M1D | Structure of BIR1 from CIAP1 | x-ray diffraction | A, B | — | — |
| 3MUP | cIAP1-BIR3 domain in complex with the Smac-mimetic compound Smac037 | x-ray diffraction | A, B, C, D | — | — |
| 3MUP | CIAP1-BIR3 domain in complex with the smac-mimetic compound SMAC037 | x-ray diffraction | A, B, C, D | — | — |
| 3OZ1 | cIAP1-BIR3 domain in complex with the Smac-mimetic compound Smac066 | x-ray diffraction | A, B, C, D | — | — |
| 3OZ1 | CIAP1-BIR3 domain in complex with the smac-mimetic compound SMAC066 | x-ray diffraction | A, B, C, D | — | — |
| 3T6P | IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization | x-ray diffraction | A | — | — |
| 3T6P | Iap antagonist-induced conformational change in CIAP1 promotes E3 ligase activation via dimerization | x-ray diffraction | A | — | — |
| 3UW4 | Crystal structure of cIAP1 BIR3 bound to GDC0152 | x-ray diffraction | A | — | — |
| 3UW4 | Crystal structure of CIAP1 BIR3 bound to GDC0152 | x-ray diffraction | A | — | — |
| 4EB9 | cIAP1-BIR3 in complex with a divalent Smac mimetic | x-ray diffraction | A, B, C, D | — | — |
| 4EB9 | CIAP1-BIR3 in complex with a divalent smac mimetic | x-ray diffraction | A, B, C, D | — | — |
| 4HY4 | Crystal structure of cIAP1 BIR3 bound to T3170284 | x-ray diffraction | A, B | — | — |
| 4HY4 | Crystal structure of CIAP1 BIR3 bound to T3170284 | x-ray diffraction | A, B | — | — |
| 4HY5 | Crystal structure of cIAP1 BIR3 bound to T3256336 | x-ray diffraction | A, B | — | — |
| 4HY5 | Crystal structure of CIAP1 BIR3 bound to T3256336 | x-ray diffraction | A, B | — | — |
| 4KMN | Structure of cIAP1-BIR3 and inhibitor | x-ray diffraction | A | — | — |
| 4KMN | Structure of CIAP1-BIR3 and inhibitor | x-ray diffraction | A | — | — |
| 4LGE | Crystal structure of clAP1 BIR3 bound to T3261256 | x-ray diffraction | A, B | — | — |
| 4LGE | Crystal structure of CLAP1 BIR3 bound to T3261256 | x-ray diffraction | A, B | — | — |
| 4LGU | Crystal structure of clAP1 BIR3 bound to T3226692 | x-ray diffraction | A, B | — | — |
| 4LGU | Crystal structure of CLAP1 BIR3 bound to T3226692 | x-ray diffraction | A, B | — | — |
| 4MTI | Crystal structure of cIAP1 BIR3 bound to T3258042 | x-ray diffraction | A, B | — | — |
| 4MTI | Crystal structure of CIAP1 BIR3 bound to T3258042 | x-ray diffraction | A, B | — | — |
| 4MU7 | Crystal structure of cIAP1 BIR3 bound to T3450325 | x-ray diffraction | A, B | — | — |
| 4MU7 | Crystal structure of CIAP1 BIR3 bound to T3450325 | x-ray diffraction | A, B | — | — |
| 5M6N | Small Molecule inhibitors of IAP | x-ray diffraction | A, B | ZN, SO4, 7H9 | — |
| 5M6N | Small molecule inhibitors of iap | x-ray diffraction | A, B | ZN, SO4, 7H9 | — |
| 6EXW | Crystal structure of CIAP1-BIR3 in complex with a covalently bound sm | x-ray diffraction | A, C | ZN | — |
| 6HPR | Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub | x-ray diffraction | A | ZN | — |
| 6HPR | Crystal structure of CIAP1 ring domain bound to UBCH5B-ub and a non- covalent ub | x-ray diffraction | A | ZN | — |
| 6W74 | Structure of cIAP with compound 15 | x-ray diffraction | A | ZN, TKY | — |
| 6W74 | Structure of ciap with compound 15 | x-ray diffraction | A | ZN, TKY | — |
| 6W7O | Ternary complex structure - BTK cIAP compound 17 | x-ray diffraction | C, D | TL7, ZN | 4 (best 0.81) |
| 6W7O | Ternary complex structure - btk ciap compound 17 | x-ray diffraction | C, D | TL7, ZN | — |
| 6W8I | Ternary complex structure - BTK cIAP compound 15 | x-ray diffraction | D, E, F | TKY, ZN | 8 (best 0.78) |
| 6W8I | Ternary complex structure - btk ciap compound 15 | x-ray diffraction | D, E, F | TKY, ZN | — |
| 7QGJ | Apo structure of BIR2 Domain of BIRC2 | x-ray diffraction | A, B | ZN | — |
| 7QGJ | Apo structure of BIR2 domain of BIRC2 | x-ray diffraction | A, B | ZN | — |
| 7TRL | Crystal structure of human BIRC2 BIR3 domain in complex with histone H3 | x-ray diffraction | A | ZN | — |
| 7TRM | Crystal structure of human BIRC2 BIR3 domain in complex with inhibitor LCL-161 | x-ray diffraction | A | ZN, IUN | — |
| 8DSF | Structure of cIAP1 with BCCov | x-ray diffraction | A, B, C, D | ZN, TO0 | 2 (best 0.36) |
| 8DSO | Structure of cIAP1, BTK and BCCov | x-ray diffraction | D | TOO, ZN | 1 (best 0.76) |
| Q13490 | AlphaFold monomer V2.0 prediction for baculoviral iap repeat- containing protein 2 (Q13490) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 17 records
- TKY · 14-{[(3S)-2-(N-methyl-L-alanyl-3-methyl-L-valyl)-3-{[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}-1, 2,3,4-tetrahydroisoquinolin-7-yl]oxy}-3,6,9,12-tetraoxatetradecan-1-yl (3R)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate · in 4 records
- 7H9 · 1-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2~{R},5~{R})-5-methyl-2-[[(3~{R})-3-methylmorpholin-4-yl]methyl]piperazin-4-ium-1-yl]ethanone · in 2 records
- SO4 · Sulfate ion · in 2 records
- TL7 · [5-({[(3S)-2-(N-methyl-L-alanyl-3-methyl-L-valyl)-3-{[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}-1, 2,3,4-tetrahydroisoquinolin-7-yl]oxy}methyl)pyrazin-2-yl]methyl (3R)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate · in 2 records
- IUN · Lcl-161 · in 1 record
- TO0 · (4S)-4-[2-(2-{4-[(2E)-4-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}-4-oxobut-2-en-1-yl]piperazin-1-yl}ethoxy)acetamido]-1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-L-prolinamide unbound form · in 1 record
- TOO · (4S)-4-[2-(2-{4-[(2E)-4-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}-4-oxobut-2-en-1-yl]piperazin-1-yl}ethoxy)acetamido]-1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-L-prolinamide bound form · in 1 record
Experiment against prediction
- 3T6P chain A against the predicted model Q13490: TM-score 0.99, RMSD 0.62 Å
- 3T6P chain A against the predicted model Q13490: TM-score 0.99, RMSD 0.62 Å
- 8DSF chain A against the predicted model Q13490: TM-score 0.99, RMSD 0.31 Å
- 8DSF chain B against the predicted model Q13490: TM-score 0.99, RMSD 0.46 Å
- 7TRM chain A against the predicted model Q13490: TM-score 0.99, RMSD 0.42 Å
- 3D9U chain A against the predicted model Q13490: TM-score 0.99, RMSD 0.43 Å
- 3D9U chain A against the predicted model Q13490: TM-score 0.99, RMSD 0.43 Å
- 4LGE chain B against the predicted model Q13490: TM-score 0.99, RMSD 0.44 Å
- 4LGE chain B against the predicted model Q13490: TM-score 0.99, RMSD 0.44 Å
- 6W8I chain D against the predicted model Q13490: TM-score 0.98, RMSD 0.44 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.