UniProt Q13469
Nuclear factor of activated T-cells, cytoplasmic 2 (Q13469)
Nuclear factor of activated T-cells, cytoplasmic 2 (UniProt Q13469): 17 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 4 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q13469
- Protein
- Nuclear factor of activated T-cells, cytoplasmic 2
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 4 · 0 records with a druggable one
Structures
18 records of Q13469 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A02 | Structure of the DNA binding domains of nfat, fos and jun bound to DNA | x-ray diffraction | N | — | — |
| 1A02 | Structure of the DNA binding domains of nfat, fos and jun bound to DNA | x-ray diffraction | N | — | — |
| 1OWR | Crystal structure of human NFAT1 bound monomerically to DNA | x-ray diffraction | M, N, P, Q | — | — |
| 1OWR | Crystal structure of human NFAT1 bound monomerically to DNA | x-ray diffraction | M, N, P, Q | — | — |
| 1P7H | Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element | x-ray diffraction | L, M, N, O | — | — |
| 1P7H | Structure of NFAT1 bound as a dimer to the HIV-1 ltr kb element | x-ray diffraction | L, M, N, O | — | — |
| 1PZU | An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site | x-ray diffraction | B, D, H, I, L, M | — | — |
| 1PZU | An asymmetric NFAT1-rhr homodimer on a pseudo-palindromic, kappa-B site | x-ray diffraction | B, D, H, I, L, M | — | — |
| 1S9K | Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site | x-ray diffraction | C | — | — |
| 1S9K | Crystal structure of human NFAT1 and fos-jun on the il-2 ARRE1 site | x-ray diffraction | C | — | — |
| 2AS5 | Structure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA. | x-ray diffraction | N, M | — | — |
| 2AS5 | Structure of the DNA binding domains of nfat and FOXP2 bound specifically to DNA. | x-ray diffraction | N, M | — | — |
| 2O93 | Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element | x-ray diffraction | L, M, O | — | — |
| 2O93 | Crystal structure of nfat bound to the HIV-1 ltr tandem kappab enhancer element | x-ray diffraction | L, M, O | — | — |
| 3QRF | Structure of a domain-swapped FOXP3 dimer | x-ray diffraction | N, M | — | — |
| 3QRF | Structure of a domain-swapped FOXP3 dimer | x-ray diffraction | N, M | — | — |
| 8R3F | C-terminal Rel-homology Domain of NFAT1 | x-ray diffraction | A, B | XS8 | 2 (best 0.46) |
| Q13469 | AlphaFold monomer V2.0 prediction for nuclear factor of activated T-cells, cytoplasmic 2 (Q13469) | predicted | A | — | 2 (best 0.41) |
Ligands
- XS8 · (4~{S})-6-fluoranyl-3,4-dihydro-2~{H}-chromen-4-amine · in 1 record
Experiment against prediction
- 8R3F chain B against the predicted model Q13469: TM-score 0.99, RMSD 0.45 Å
- 8R3F chain A against the predicted model Q13469: TM-score 0.99, RMSD 0.46 Å
- 2O93 chain M against the predicted model Q13469: TM-score 0.84, RMSD 2.97 Å
- 2O93 chain M against the predicted model Q13469: TM-score 0.84, RMSD 2.97 Å
- 1PZU chain B against the predicted model Q13469: TM-score 0.72, RMSD 3.85 Å
- 1PZU chain B against the predicted model Q13469: TM-score 0.72, RMSD 3.85 Å
- 1OWR chain M against the predicted model Q13469: TM-score 0.68, RMSD 3.32 Å
- 1OWR chain M against the predicted model Q13469: TM-score 0.68, RMSD 3.32 Å
- 2O93 chain L against the predicted model Q13469: TM-score 0.67, RMSD 3.60 Å
- 2O93 chain L against the predicted model Q13469: TM-score 0.67, RMSD 3.60 Å
Elsewhere
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