UniProt Q13404
Ubiquitin-conjugating enzyme E2 variant 1 (Q13404)
Ubiquitin-conjugating enzyme E2 variant 1 (UniProt Q13404), EC 6.3.2.19: 8 experimental structures and 1 predicted model on GenesisL1, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13404
- Protein
- Ubiquitin-conjugating enzyme E2 variant 1
- EC
- 6.3.2.19
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 15 · 2 records with a druggable one
Structures
9 records of Q13404 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2A4D | Structure of the human ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) | x-ray diffraction | A | — | — |
| 2A4D | Structure of the human ubiquitin-conjugating enzyme E2 variant 1 (uev- 1) | x-ray diffraction | A | — | — |
| 2C2V | Crystal structure of the CHIP-UBC13-UEV1a complex | x-ray diffraction | C, F, I, L | — | — |
| 2C2V | Crystal structure of the chip-UBC13-UEV1A complex | x-ray diffraction | C, F, I, L | — | 10 (best 0.73) |
| 2HLW | Solution Structure of the Human Ubiquitin-conjugating Enzyme Variant Uev1a | solution nmr | A | — | — |
| 2HLW | Solution structure of the human ubiquitin-conjugating enzyme variant UEV1A | solution nmr | A | — | — |
| 6D6I | Ube2V1 in complex with ubiquitin variant Ubv.V1.1 and Ube2N/Ubc13 | x-ray diffraction | A, D | — | 5 (best 0.73) |
| 6D6I | UBE2V1 in complex with ubiquitin variant UBV.V1.1 and UBE2N/UBC13 | x-ray diffraction | A, D | — | — |
| Q13404 | AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 variant 1 (Q13404) | predicted | A | — | — |
Experiment against prediction
- 6D6I chain A against the predicted model Q13404: TM-score 0.98, RMSD 0.59 Å
- 6D6I chain A against the predicted model Q13404: TM-score 0.98, RMSD 0.59 Å
- 2C2V chain F against the predicted model Q13404: TM-score 0.98, RMSD 0.71 Å
- 2C2V chain F against the predicted model Q13404: TM-score 0.98, RMSD 0.71 Å
- 2C2V chain C against the predicted model Q13404: TM-score 0.97, RMSD 1.00 Å
- 2C2V chain C against the predicted model Q13404: TM-score 0.97, RMSD 1.00 Å
- 2A4D chain A against the predicted model Q13404: TM-score 0.96, RMSD 0.80 Å
- 2A4D chain A against the predicted model Q13404: TM-score 0.96, RMSD 0.80 Å
- 2HLW chain A against the predicted model Q13404: TM-score 0.77, RMSD 1.71 Å
- 2HLW chain A against the predicted model Q13404: TM-score 0.77, RMSD 1.71 Å
Elsewhere
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