UniProt Q13393

Phospholipase D1, chimeric constuct (Q13393)

Phospholipase D1, chimeric constuct (UniProt Q13393), EC 3.1.4.4: 3 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: Q13393
Protein: Phospholipase D1, chimeric constuct
EC: 3.1.4.4
Experimental structures: 3
Predicted models: 1
Ligands: 2
Pockets: 35 · 2 records with a druggable one

Structures

4 records of Q13393 in the MolNFT archive: 3 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6OHR	Structure of compound 5 bound human Phospholipase D1 catalytic domain	x-ray diffraction	A, B, C, D, E, F	MKG	20 (best 0.83)
6OHR	Structure of compound 5 bound human phospholipase D1 catalytic domain	x-ray diffraction	A, B, C, D, E, F	MKG	—
6U8Z	Crystal structure of catalytic domain of human phospholipase D1	x-ray diffraction	A	PO3	—
Q13393	AlphaFold monomer V2.0 prediction for phospholipase D1 (Q13393)	predicted	A	—	15 (best 0.80)

Ligands

MKG · 4-fluoro-N-{(2S)-1-[(5R)-5-(3-fluorophenyl)-2-oxo-1-oxa-3,9-diazaspiro[5.5]undecan-9-yl]propan-2-yl}benzamide · in 2 records
PO3 · Phosphite ion · in 1 record

Experiment against prediction

6U8Z chain A against the predicted model Q13393: TM-score 0.98, RMSD 1.18 Å
6OHR chain D against the predicted model Q13393: TM-score 0.98, RMSD 1.37 Å
6OHR chain D against the predicted model Q13393: TM-score 0.98, RMSD 1.37 Å
6OHR chain E against the predicted model Q13393: TM-score 0.98, RMSD 1.40 Å
6OHR chain E against the predicted model Q13393: TM-score 0.98, RMSD 1.40 Å
6OHR chain B against the predicted model Q13393: TM-score 0.98, RMSD 1.56 Å
6OHR chain B against the predicted model Q13393: TM-score 0.98, RMSD 1.56 Å
6OHR chain C against the predicted model Q13393: TM-score 0.98, RMSD 1.54 Å
6OHR chain C against the predicted model Q13393: TM-score 0.98, RMSD 1.54 Å
6OHR chain A against the predicted model Q13393: TM-score 0.98, RMSD 1.57 Å

Elsewhere

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