UniProt Q13370
Cgmp-inhibited 3',5'-cyclic phosphodiesterase B (Q13370)
Cgmp-inhibited 3',5'-cyclic phosphodiesterase B (UniProt Q13370): 4 experimental structures and 1 predicted model on GenesisL1, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13370
- Protein
- Cgmp-inhibited 3',5'-cyclic phosphodiesterase B
- Experimental structures
- 4
- Predicted models
- 1
- Pockets
- 12 · 1 record with a druggable one
Structures
5 records of Q13370 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1SO2 | CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B In COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR | x-ray diffraction | A, B, C, D | — | — |
| 1SO2 | Catalytic domain of human phosphodiesterase 3B in complex with a dihydropyridazine inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 1SOJ | Catalytic domain of human phosphodiesterase 3B in complex with ibmx | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1SOJ | Catalytic domain of human phosphodiesterase 3B in complex with ibmx | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| Q13370 | AlphaFold monomer V2.0 prediction for cgmp-inhibited 3',5'-cyclic phosphodiesterase B (Q13370) | predicted | A | — | 12 (best 0.72) |
Experiment against prediction
- 1SOJ chain A against the predicted model Q13370: TM-score 0.99, RMSD 0.76 Å
- 1SOJ chain A against the predicted model Q13370: TM-score 0.99, RMSD 0.76 Å
- 1SO2 chain A against the predicted model Q13370: TM-score 0.99, RMSD 1.12 Å
- 1SO2 chain A against the predicted model Q13370: TM-score 0.99, RMSD 1.12 Å
- 1SO2 chain D against the predicted model Q13370: TM-score 0.99, RMSD 0.92 Å
- 1SO2 chain D against the predicted model Q13370: TM-score 0.99, RMSD 0.92 Å
- 1SOJ chain B against the predicted model Q13370: TM-score 0.98, RMSD 1.50 Å
- 1SOJ chain B against the predicted model Q13370: TM-score 0.98, RMSD 1.50 Å
- 1SO2 chain C against the predicted model Q13370: TM-score 0.97, RMSD 1.46 Å
- 1SO2 chain C against the predicted model Q13370: TM-score 0.97, RMSD 1.46 Å
Elsewhere
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