UniProt Q13330
Metastasis-associated protein MTA1 (Q13330)
Metastasis-associated protein MTA1 (UniProt Q13330): 20 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 58 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13330
- Protein
- Metastasis-associated protein MTA1
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 58 · 5 records with a druggable one
Structures
21 records of Q13330 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4BKX | The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex | x-ray diffraction | A | — | — |
| 4BKX | The structure of HDAC1 in complex with the dimeric ELM2-sant domain of MTA1 from the nurd complex | x-ray diffraction | A | — | — |
| 4PBY | Structure of the human RbAp48-MTA1(656-686) complex | x-ray diffraction | C, D | — | — |
| 4PBY | Structure of the human RBAP48-MTA1(656-686) complex | x-ray diffraction | C, D | — | — |
| 4PBZ | Structure of the human RbAp48-MTA1(670-695) complex | x-ray diffraction | B | — | — |
| 4PBZ | Structure of the human RBAP48-MTA1(670-695) complex | x-ray diffraction | B | — | — |
| 4PC0 | Structure of the human RbAp48-MTA1(670-711) complex | x-ray diffraction | C, D | — | — |
| 4PC0 | Structure of the human RBAP48-MTA1(670-711) complex | x-ray diffraction | C, D | — | — |
| 5FXY | Structure of the human RBBP4:MTA1(464-546) complex | x-ray diffraction | B, D, F, H | — | — |
| 5FXY | Structure of the human RBBP4:MTA1(464-546) complex | x-ray diffraction | B, D, F, H | — | — |
| 5ICN | HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4 | x-ray diffraction | A | IHP | — |
| 5ICN | HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4 | x-ray diffraction | A | — | — |
| 6G16 | Structure of the human RBBP4:MTA1(464-546) complex showing loop exchange | x-ray diffraction | B, D, F, H | — | 6 (best 0.82) |
| 6G16 | Structure of the human RBBP4:MTA1(464-546) complex showing loop exchange | x-ray diffraction | B, D, F, H | — | — |
| 7AO8 | Structure of the MTA1/HDAC1/MBD2 NURD deacetylase complex | electron microscopy | D, A | IHP | 17 (best 0.71) |
| 7AO8 | Structure of the MTA1/HDAC1/MBD2 nurd deacetylase complex | electron microscopy | D, A | IHP | — |
| 7AO9 | Structure of the core MTA1/HDAC1/MBD2 NURD deacetylase complex | electron microscopy | D, A | IHP | 12 (best 0.73) |
| 7AO9 | Structure of the core MTA1/HDAC1/MBD2 nurd deacetylase complex | electron microscopy | D, A | IHP | — |
| 7AOA | Structure of the extended MTA1/HDAC1/MBD2/RBBP4 NURD deacetylase complex | electron microscopy | D, A | IHP | 18 (best 0.72) |
| 7AOA | Structure of the extended MTA1/HDAC1/MBD2/RBBP4 nurd deacetylase complex | electron microscopy | D, A | IHP | — |
| Q13330 | AlphaFold monomer V2.0 prediction for metastasis-associated protein MTA1 (Q13330) | predicted | A | — | 5 (best 0.66) |
Ligands
- IHP · Inositol hexakisphosphate · in 7 records
Experiment against prediction
- 7AO9 chain D against the predicted model Q13330: TM-score 0.85, RMSD 2.52 Å
- 7AO9 chain D against the predicted model Q13330: TM-score 0.85, RMSD 2.52 Å
- 5ICN chain A against the predicted model Q13330: TM-score 0.85, RMSD 2.52 Å
- 5ICN chain A against the predicted model Q13330: TM-score 0.85, RMSD 2.52 Å
- 7AO9 chain A against the predicted model Q13330: TM-score 0.85, RMSD 2.52 Å
- 4BKX chain A against the predicted model Q13330: TM-score 0.85, RMSD 2.52 Å
- 4BKX chain A against the predicted model Q13330: TM-score 0.85, RMSD 2.52 Å
- 6G16 chain F against the predicted model Q13330: TM-score 0.80, RMSD 2.40 Å
- 5FXY chain F against the predicted model Q13330: TM-score 0.79, RMSD 2.22 Å
- 5FXY chain F against the predicted model Q13330: TM-score 0.79, RMSD 2.22 Å
Elsewhere
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