UniProt Q12756
Kinesin-like protein KIF1A (Q12756)
Kinesin-like protein KIF1A (UniProt Q12756): 19 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 59 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12756
- Protein
- Kinesin-like protein KIF1A
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 59 · 7 records with a druggable one
Structures
20 records of Q12756 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4EGX | Crystal structure of KIF1A CC1-FHA tandem | x-ray diffraction | A, B, C, D | — | — |
| 4EGX | Crystal structure of KIF1A CC1-fha tandem | x-ray diffraction | A, B, C, D | — | — |
| 4EJQ | Crystal structure of KIF1A C-CC1-FHA | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4EJQ | Crystal structure of KIF1A C-CC1-fha | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4UXO | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | C | — | — |
| 4UXO | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | C | — | — |
| 4UXP | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | C | — | — |
| 4UXP | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | C | — | — |
| 4UXR | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | C | — | — |
| 4UXR | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | C | — | — |
| 4UXS | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | C | — | — |
| 4UXS | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in… | electron microscopy | C | — | — |
| 8UTO | KIF1A[1-393] AMP-PNP bound two-heads-bound state in complex with a microtubule - class T2L1 | electron microscopy | K, N | MG, ANP | 10 (best 0.82) |
| 8UTP | KIF1A[1-393] - AMP-PNP two-heads-bound state in complex with a microtubule - class T3L1 | electron microscopy | K, N | MG, ANP | 9 (best 0.82) |
| 8UTQ | KIF1A[1-393] AMP-PNP bound one-head-bound state in complex with a microtubule - class T1L02* | electron microscopy | K | MG, ANP | 9 (best 0.82) |
| 8UTT | KIF1A[1-393] P305L mutant AMP-PNP bound two-heads-bound state in complex with a microtubule | electron microscopy | K, N | MG, ANP | 7 (best 0.85) |
| 8UTU | KIF1A[1-393] P305L mutant AMP-PNP bound one and two heads bound states merged, in complex with a… | electron microscopy | K | MG, ANP | 7 (best 0.84) |
| 8UTV | KIF1A[1-393] P305L mutant ADP bound in complex with a microtubule | electron microscopy | K | ADP | 8 (best 0.81) |
| 8UTY | KIF1A[1-393] P364L mutant AMP-PNP bound two-heads-bound state in complex with a microtubule | electron microscopy | K, N | MG, ANP | 9 (best 0.83) |
| Q12756 | AlphaFold monomer V2.0 prediction for kinesin-like protein KIF1A (Q12756) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4UXP chain C against the predicted model Q12756: TM-score 0.93, RMSD 1.96 Å
- 4UXP chain C against the predicted model Q12756: TM-score 0.93, RMSD 1.96 Å
- 8UTY chain K against the predicted model Q12756: TM-score 0.93, RMSD 2.09 Å
- 4UXR chain C against the predicted model Q12756: TM-score 0.93, RMSD 2.02 Å
- 4UXR chain C against the predicted model Q12756: TM-score 0.93, RMSD 2.02 Å
- 8UTT chain K against the predicted model Q12756: TM-score 0.92, RMSD 2.23 Å
- 8UTU chain K against the predicted model Q12756: TM-score 0.92, RMSD 2.23 Å
- 8UTO chain K against the predicted model Q12756: TM-score 0.92, RMSD 2.27 Å
- 8UTP chain K against the predicted model Q12756: TM-score 0.92, RMSD 2.29 Å
- 4EJQ chain G against the predicted model Q12756: TM-score 0.91, RMSD 1.56 Å
Elsewhere
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