UniProt Q12629
Pyruvate decarboxylase (Q12629)
Pyruvate decarboxylase (UniProt Q12629), EC 4.1.1.1: 7 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12629
- Protein
- Pyruvate decarboxylase
- EC
- 4.1.1.1
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 15 · 2 records with a druggable one
Structures
8 records of Q12629 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VJY | Pyruvate decarboxylase from Kluyveromyces lactis in complex with the substrate analogue methyl… | x-ray diffraction | A, B, C, D | — | — |
| 2VJY | Pyruvate decarboxylase from kluyveromyces lactis in complex with the substrate analogue methyl… | x-ray diffraction | A, B, C, D | — | — |
| 2VK4 | Crystal structure of pyruvate decarboxylase from Kluyveromyces lactis | x-ray diffraction | A, B, C, D | — | — |
| 2VK4 | Crystal structure of pyruvate decarboxylase from kluyveromyces lactis | x-ray diffraction | A, B, C, D | — | — |
| 6EFG | Pyruvate decarboxylase from kluyveromyces lactis | x-ray diffraction | A, B, D, E | TPP, MG | — |
| 6EFH | Pyruvate decarboxylase from Kluyveromyces lactis soaked with pyruvamide | x-ray diffraction | A, B | PY0, TPP, MG | 11 (best 0.84) |
| 6EFH | Pyruvate decarboxylase from kluyveromyces lactis soaked with pyruvamide | x-ray diffraction | A, B | PY0, TPP, MG | — |
| Q12629 | AlphaFold monomer V2.0 prediction for pyruvate decarboxylase (Q12629) | predicted | A | — | 4 (best 0.56) |
Ligands
Experiment against prediction
- 2VJY chain A against the predicted model Q12629: TM-score 1.00, RMSD 0.52 Å
- 2VJY chain A against the predicted model Q12629: TM-score 1.00, RMSD 0.52 Å
- 6EFG chain D against the predicted model Q12629: TM-score 0.98, RMSD 1.23 Å
- 6EFG chain A against the predicted model Q12629: TM-score 0.98, RMSD 1.30 Å
- 6EFG chain B against the predicted model Q12629: TM-score 0.98, RMSD 1.47 Å
- 6EFG chain E against the predicted model Q12629: TM-score 0.98, RMSD 1.42 Å
- 2VK4 chain A against the predicted model Q12629: TM-score 0.96, RMSD 1.86 Å
- 2VK4 chain A against the predicted model Q12629: TM-score 0.96, RMSD 1.86 Å
- 2VK4 chain C against the predicted model Q12629: TM-score 0.96, RMSD 1.90 Å
- 2VK4 chain C against the predicted model Q12629: TM-score 0.96, RMSD 1.90 Å
Elsewhere
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