UniProt Q12518
Epsin-1 (Q12518)
Epsin-1 (UniProt Q12518): 7 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12518
- Protein
- Epsin-1
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 1 · 1 record with a druggable one
Structures
8 records of Q12518 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5AHV | Cryo-EM structure of helical ANTH and ENTH tubules on PI(4,5)P2-containing membranes | electron microscopy | E | — | — |
| 5AHV | Cryo-EM structure of helical anth and enth tubules on PI(4,5)P2- containing membranes | electron microscopy | E | — | — |
| 5LOZ | Structure of yeast ENT1 enth domain | x-ray diffraction | A | — | — |
| 5ONF | The ENTH domain from epsin-1 | x-ray diffraction | A, B, C | — | — |
| 5ONF | The enth domain from epsin-1 | x-ray diffraction | A, B, C | — | — |
| 7B2L | Structure of the endocytic adaptor complex aenth | electron microscopy | A, C, F, H, K, M, P, R | PIO | — |
| 9EYT | Crystal structure of Yeast Clathrin Heavy Chain N-terminal domain bound to Epsin-1 peptide (LIDL) | x-ray diffraction | E, G, M | — | 1 (best 0.77) |
| Q12518 | AlphaFold monomer V2.0 prediction for epsin-1 (Q12518) | predicted | A | — | — |
Ligands
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 1 record
Experiment against prediction
- 5LOZ chain A against the predicted model Q12518: TM-score 0.96, RMSD 0.96 Å
- 7B2L chain A against the predicted model Q12518: TM-score 0.96, RMSD 1.01 Å
- 7B2L chain F against the predicted model Q12518: TM-score 0.96, RMSD 1.01 Å
- 7B2L chain K against the predicted model Q12518: TM-score 0.96, RMSD 1.01 Å
- 7B2L chain P against the predicted model Q12518: TM-score 0.96, RMSD 1.01 Å
- 7B2L chain C against the predicted model Q12518: TM-score 0.95, RMSD 1.07 Å
- 7B2L chain H against the predicted model Q12518: TM-score 0.95, RMSD 1.07 Å
- 7B2L chain M against the predicted model Q12518: TM-score 0.95, RMSD 1.07 Å
- 7B2L chain R against the predicted model Q12518: TM-score 0.95, RMSD 1.07 Å
- 5ONF chain B against the predicted model Q12518: TM-score 0.92, RMSD 1.59 Å
Elsewhere
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