UniProt Q12499
Nucleolar protein 58 (Q12499)
Nucleolar protein 58 (UniProt Q12499): 18 experimental structures and 1 predicted model on GenesisL1, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12499
- Protein
- Nucleolar protein 58
- Experimental structures
- 18
- Predicted models
- 1
- Pockets
- 13 · 8 records with a druggable one
Structures
19 records of Q12499 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5WLC | The complete structure of the small subunit processome | electron microscopy | SB | — | — |
| 5WYJ | Cryo-EM structure of the 90S small subunit pre-ribosome (Dhr1-depleted, Enp1-TAP, state 1) | electron microscopy | 3E | — | 1 (best 0.85) |
| 5WYK | Cryo-EM structure of the 90S small subunit pre-ribosome (Mtr4-depleted, Enp1-TAP) | electron microscopy | 3E | — | — |
| 6LQP | Cryo-EM structure of 90S small subunit preribosomes in transition states (State A) | electron microscopy | 3E | — | — |
| 6LQQ | Cryo-EM structure of 90S small subunit preribosomes in transition states (State B) | electron microscopy | 3E | — | — |
| 6LQR | Cryo-EM structure of 90S small subunit preribosomes in transition states (State C) | electron microscopy | 3E | — | — |
| 6LQS | Cryo-EM structure of 90S small subunit preribosomes in transition states (State D) | electron microscopy | 3E | — | — |
| 6LQT | Cryo-EM structure of 90S small subunit preribosomes in transition states (State E) | electron microscopy | 3E | — | — |
| 6LQU | Cryo-EM structure of 90S small subunit preribosomes in transition states (State A1) | electron microscopy | 3E | — | — |
| 6LQV | Cryo-EM structure of 90S small subunit preribosomes in transition states (State C1) | electron microscopy | 3E | — | — |
| 6ZQC | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1 | electron microscopy | CE | — | — |
| 6ZQE | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-A (Poly-Ala) | electron microscopy | CE | — | 1 (best 0.83) |
| 7AJT | Cryo-EM structure of the 90S-exosome super-complex (state Pre-A1-exosome) | electron microscopy | CE | — | 1 (best 0.85) |
| 7AJU | Cryo-EM structure of the 90S-exosome super-complex (state Post-A1-exosome) | electron microscopy | CE | — | 2 (best 0.86) |
| 7D4I | Cryo-EM structure of 90S small ribosomal precursors complex with the DEAH-box RNA helicase Dhr1… | electron microscopy | 3E | — | 2 (best 0.85) |
| 7D5S | Cryo-EM structure of 90S preribosome with inactive Utp24 (state A2) | electron microscopy | 3E | — | 2 (best 0.87) |
| 7D5T | Cryo-EM structure of 90S preribosome with inactive Utp24 (state F1) | electron microscopy | 3E | — | 1 (best 0.84) |
| 7D63 | Cryo-EM structure of 90S preribosome with inactive Utp24 (state C) | electron microscopy | 3E | — | 2 (best 0.85) |
| Q12499 | AlphaFold monomer V2.0 prediction for nucleolar protein 58 (Q12499) | predicted | A | — | 1 (best 0.36) |
Experiment against prediction
- 5WYK chain 3E against the predicted model Q12499: TM-score 0.91, RMSD 2.37 Å
- 5WYJ chain 3E against the predicted model Q12499: TM-score 0.91, RMSD 2.40 Å
- 5WLC chain SB against the predicted model Q12499: TM-score 0.87, RMSD 2.60 Å
- 7AJT chain CE against the predicted model Q12499: TM-score 0.87, RMSD 2.73 Å
- 6LQP chain 3E against the predicted model Q12499: TM-score 0.87, RMSD 2.65 Å
- 6LQQ chain 3E against the predicted model Q12499: TM-score 0.87, RMSD 2.65 Å
- 6LQR chain 3E against the predicted model Q12499: TM-score 0.87, RMSD 2.65 Å
- 6LQU chain 3E against the predicted model Q12499: TM-score 0.87, RMSD 2.65 Å
- 6LQV chain 3E against the predicted model Q12499: TM-score 0.87, RMSD 2.65 Å
- 7D63 chain 3E against the predicted model Q12499: TM-score 0.87, RMSD 2.65 Å
Elsewhere
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