UniProt Q12250
26S proteasome regulatory subunit RPN5 (Q12250)
26S proteasome regulatory subunit RPN5 (UniProt Q12250): 31 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12250
- Protein
- 26S proteasome regulatory subunit RPN5
- Experimental structures
- 31
- Predicted models
- 1
- Pockets
- 6 · 2 records with a druggable one
Structures
32 records of Q12250 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J47 | Formation of an intricate helical bundle dictates the assembly of the 26S proteasome lid | electron microscopy | P | — | — |
| 3J47 | Formation of an intricate helical bundle dictates the assembly of the 26S proteasome lid | electron microscopy | P | — | — |
| 3JCK | Structure of the yeast 26S proteasome lid sub-complex | electron microscopy | B | — | — |
| 3JCK | Structure of the yeast 26S proteasome lid sub-complex | electron microscopy | B | — | — |
| 3JCO | Structure of yeast 26S proteasome in M1 state derived from Titan dataset | electron microscopy | P | — | — |
| 3JCP | Structure of yeast 26S proteasome in M2 state derived from Titan dataset | electron microscopy | P | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | P | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | P | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | P | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | P | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | P | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | P | — | — |
| 5A5B | Structure of the 26S proteasome-Ubp6 complex | electron microscopy | P | — | — |
| 5A5B | Structure of the 26S proteasome-UBP6 complex | electron microscopy | P | — | — |
| 5MPB | 26S proteasome in presence of AMP-PNP (s3) | electron microscopy | P | — | — |
| 5MPC | 26S proteasome in presence of BeFx (s4) | electron microscopy | P | — | — |
| 5MPD | 26S proteasome in presence of ATP (s1) | electron microscopy | P | — | 2 (best 0.77) |
| 5MPD | 26S proteasome in presence of ATP (S1) | electron microscopy | P | — | — |
| 5MPE | 26S proteasome in presence of ATP (s2) | electron microscopy | P | — | — |
| 5MPE | 26S proteasome in presence of ATP (S2) | electron microscopy | P | — | — |
| 5WVI | The resting state of yeast proteasome | electron microscopy | P | — | — |
| 5ZMR | Solution Structure of the N-terminal Domain of the Yeast Rpn5 | solution nmr | A | — | 1 (best 0.32) |
| 5ZMR | Solution structure of the N-terminal domain of the yeast RPN5 | solution nmr | A | — | — |
| 6FVT | 26S proteasome, s1 state | electron microscopy | P | — | — |
| 6FVU | 26S proteasome, s2 state | electron microscopy | P | — | — |
| 6FVV | 26S proteasome, s3 state | electron microscopy | P | — | — |
| 6FVW | 26S proteasome, s4 state | electron microscopy | P | — | — |
| 6J2C | Yeast proteasome in translocation competent state (C3-a) | electron microscopy | P | — | — |
| 6J2X | Yeast proteasome in resting state (C1-a) | electron microscopy | P | — | — |
| 7QO3 | Structure of the 26S proteasome-Ubp6 complex in the si state (Core Particle and Lid) | electron microscopy | P | — | 1 (best 0.71) |
| 7QO3 | Structure of the 26S proteasome-UBP6 complex in the si state (core particle and lid) | electron microscopy | P | — | — |
| Q12250 | AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN5 (Q12250) | predicted | A | — | 2 (best 0.30) |
Experiment against prediction
- 3JCK chain B against the predicted model Q12250: TM-score 0.92, RMSD 2.21 Å
- 3JCK chain B against the predicted model Q12250: TM-score 0.92, RMSD 2.21 Å
- 6FVT chain P against the predicted model Q12250: TM-score 0.90, RMSD 2.20 Å
- 5MPD chain P against the predicted model Q12250: TM-score 0.90, RMSD 2.26 Å
- 5MPD chain P against the predicted model Q12250: TM-score 0.90, RMSD 2.26 Å
- 7QO3 chain P against the predicted model Q12250: TM-score 0.90, RMSD 2.33 Å
- 7QO3 chain P against the predicted model Q12250: TM-score 0.90, RMSD 2.33 Å
- 6FVU chain P against the predicted model Q12250: TM-score 0.90, RMSD 2.65 Å
- 6FVW chain P against the predicted model Q12250: TM-score 0.90, RMSD 2.47 Å
- 5MPE chain P against the predicted model Q12250: TM-score 0.89, RMSD 2.61 Å
Elsewhere
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