UniProt Q12216
E3 SUMO-protein ligase SIZ2 (Q12216)
E3 SUMO-protein ligase SIZ2 (UniProt Q12216), EC 2.3.2.-: 2 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12216
- Protein
- E3 SUMO-protein ligase SIZ2
- EC
- 2.3.2.-
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 11 · 1 record with a druggable one
Structures
3 records of Q12216 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6U75 | Crystal Structure of S. Cerevisiae SUMO E3 Ligase SIZ2 | x-ray diffraction | A, B | ZN | 6 (best 0.49) |
| 6U75 | Crystal structure of S. cerevisiae sumo E3 ligase SIZ2 | x-ray diffraction | A, B | ZN | — |
| Q12216 | AlphaFold monomer V2.0 prediction for E3 sumo-protein ligase SIZ2 (Q12216) | predicted | A | — | 5 (best 0.64) |
Ligands
- ZN · Zinc ion · in 2 records
Experiment against prediction
- 6U75 chain B against the predicted model Q12216: TM-score 0.99, RMSD 0.67 Å
- 6U75 chain B against the predicted model Q12216: TM-score 0.99, RMSD 0.67 Å
- 6U75 chain A against the predicted model Q12216: TM-score 0.98, RMSD 0.81 Å
- 6U75 chain A against the predicted model Q12216: TM-score 0.98, RMSD 0.81 Å
Elsewhere
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