UniProt Q12124
Mediator of RNA polymerase II transcription subunit 2 (Q12124)
Mediator of RNA polymerase II transcription subunit 2 (UniProt Q12124): 4 experimental structures and 1 predicted model on GenesisL1, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12124
- Protein
- Mediator of RNA polymerase II transcription subunit 2
- Experimental structures
- 4
- Predicted models
- 1
- Pockets
- 12 · 3 records with a druggable one
Structures
5 records of Q12124 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7UIC | Mediator-PIC Early (Tail A) | electron microscopy | b | — | 3 (best 0.77) |
| 7UIK | Mediator-PIC Early (Tail A + Upstream DNA & Activator) | electron microscopy | b | — | 4 (best 0.80) |
| 7UIL | Mediator-PIC Early (Tail A/B Dimer) | electron microscopy | b, 1 | — | 5 (best 0.80) |
| 7UIO | Mediator-PIC Early (Composite Model) | electron microscopy | Ab, Bb | — | — |
| Q12124 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 2 (Q12124) | predicted | A | — | — |
Experiment against prediction
- 7UIO chain Ab against the predicted model Q12124: TM-score 0.59, RMSD 1.63 Å
- 7UIC chain b against the predicted model Q12124: TM-score 0.59, RMSD 1.63 Å
- 7UIL chain b against the predicted model Q12124: TM-score 0.59, RMSD 1.63 Å
- 7UIK chain b against the predicted model Q12124: TM-score 0.59, RMSD 1.63 Å
Elsewhere
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