UniProt Q12053
Norsolorinic acid synthase (Q12053)
Norsolorinic acid synthase (UniProt Q12053), EC 2.3.1.221: 11 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q12053
- Protein
- Norsolorinic acid synthase
- EC
- 2.3.1.221
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 20 · 1 record with a druggable one
Structures
12 records of Q12053 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KR5 | Solution Structure of an Acyl Carrier Protein Domain from Fungal Type I Polyketide Synthase | solution nmr | A | — | — |
| 2KR5 | Solution structure of an acyl carrier protein domain from fungal type I polyketide synthase | solution nmr | A | — | — |
| 3HRQ | The Product Template Domain from PksA with palmitate bound | x-ray diffraction | A, B | — | — |
| 3HRQ | The product template domain from pksa with palmitate bound | x-ray diffraction | A, B | — | — |
| 3HRR | The Product Template Domain from PksA with Harris Compound Bound | x-ray diffraction | A, B | — | — |
| 3HRR | The product template domain from pksa with harris compound bound | x-ray diffraction | A, B | — | — |
| 3ILS | The Thioesterase Domain from PksA | x-ray diffraction | A | — | — |
| 3ILS | The thioesterase domain from pksa | x-ray diffraction | A | — | — |
| 5KBZ | Structure of the PksA Product Template domain in complex with a phosphopantetheine mimetic | x-ray diffraction | A, B | 3B2 | — |
| 5KBZ | Structure of the pksa product template domain in complex with a phosphopantetheine mimetic | x-ray diffraction | A, B | 3B2 | — |
| 8CG4 | The organise full-length structure of the fungal non-reducing polyketide synthase (NR-PKS) PksA | electron microscopy | A, B | — | 20 (best 0.87) |
| Q12053 | AlphaFold monomer V2.0 prediction for norsolorinic acid synthase (Q12053) | predicted | A | — | — |
Ligands
- 3B2 · (14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate · in 2 records
Experiment against prediction
- 5KBZ chain B against the predicted model Q12053: TM-score 0.98, RMSD 1.25 Å
- 5KBZ chain B against the predicted model Q12053: TM-score 0.98, RMSD 1.25 Å
- 8CG4 chain B against the predicted model Q12053: TM-score 0.97, RMSD 1.85 Å
- 3HRR chain B against the predicted model Q12053: TM-score 0.97, RMSD 1.35 Å
- 3HRR chain B against the predicted model Q12053: TM-score 0.97, RMSD 1.35 Å
- 8CG4 chain A against the predicted model Q12053: TM-score 0.97, RMSD 1.88 Å
- 5KBZ chain A against the predicted model Q12053: TM-score 0.97, RMSD 1.36 Å
- 5KBZ chain A against the predicted model Q12053: TM-score 0.97, RMSD 1.36 Å
- 3HRQ chain A against the predicted model Q12053: TM-score 0.97, RMSD 1.40 Å
- 3HRQ chain A against the predicted model Q12053: TM-score 0.97, RMSD 1.40 Å
Elsewhere
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