UniProt Q0V9Z3

Proton-activated chloride channel (Q0V9Z3)

Proton-activated chloride channel (UniProt Q0V9Z3): 3 experimental structures and 1 predicted model on GenesisL1, 41 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q0V9Z3
Protein: Proton-activated chloride channel
Experimental structures: 3
Predicted models: 1
Pockets: 41 · 3 records with a druggable one

Structures

4 records of Q0V9Z3 in the MolNFT archive: 3 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
8H8D	Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR trimer bound with…	electron microscopy	A, B, C	—	11 (best 0.85)
8H8E	Structure of the dimeric Xenopus tropical acid-sensitive outwardly rectifying channel ASOR trimer…	electron microscopy	A, B, C, D, E, F	—	20 (best 0.84)
8H8F	Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR (resting state)	electron microscopy	A, B, C	—	8 (best 0.84)
Q0V9Z3	AlphaFold monomer V2.0 prediction for proton-activated chloride channel (Q0V9Z3)	predicted	A	—	2 (best 0.37)

Experiment against prediction

8H8F chain A against the predicted model Q0V9Z3: TM-score 0.83, RMSD 2.64 Å
8H8D chain B against the predicted model Q0V9Z3: TM-score 0.78, RMSD 2.63 Å
8H8E chain B against the predicted model Q0V9Z3: TM-score 0.78, RMSD 2.73 Å
8H8D chain C against the predicted model Q0V9Z3: TM-score 0.77, RMSD 2.80 Å
8H8E chain F against the predicted model Q0V9Z3: TM-score 0.77, RMSD 2.85 Å
8H8E chain C against the predicted model Q0V9Z3: TM-score 0.77, RMSD 2.82 Å
8H8D chain A against the predicted model Q0V9Z3: TM-score 0.77, RMSD 2.65 Å
8H8E chain A against the predicted model Q0V9Z3: TM-score 0.77, RMSD 2.65 Å
8H8E chain D against the predicted model Q0V9Z3: TM-score 0.77, RMSD 2.98 Å
8H8E chain E against the predicted model Q0V9Z3: TM-score 0.75, RMSD 3.07 Å

Elsewhere

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